Oncotarget

Clinical Research Papers:

Resting-state functional magnetic resonance imaging shows altered brain network topology in Type 2 diabetic patients without cognitive impairment

Guan-Qun Chen, Xin Zhang, Yue Xing, Dong Wen, Guang-Bin Cui and Ying Han _

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Oncotarget. 2017; 8:104560-104570. https://doi.org/10.18632/oncotarget.21282

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Abstract

Guan-Qun Chen1,2,3,*, Xin Zhang6,*, Yue Xing7,8, Dong Wen9,10, Guang-Bin Cui6 and Ying Han1,2,3,4,5

1Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China

2Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China

3National Clinical Research Center for Geriatric Disorders, Beijing, China

4Beijing Institute of Geriatrics, Beijing, China

5PKUCare Rehabilitation Hospital, Beijing, China

6Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China

7Radiological Sciences, Division of Clinical Neuroscience, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom

8Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom

9School of Information Science and Engineering, Yanshan University, Qinhuangdao, China

10The Key Laboratory of Software Engineering of Hebei Province, Yanshan University, Qinhuangdao, China

*These authors contributed equally to this work and are co-first authors

Correspondence to:

Ying Han, email: [email protected]

Guang-Bin Cui, email: [email protected]

Keywords: type 2 diabetes mellitus, cognitive dysfunction, functional connectivity, brain network, resting-state functional magnetic resonance imaging

Received: February 18, 2017     Accepted: August 25, 2017     Published: September 27, 2017

ABSTRACT

We analyzed topology of brain functional networks in type 2 diabetes mellitus (T2DM) patients without mild cognitive impairment. We recruited T2DM patients without mild cognitive impairment (4 males and 8 females) and healthy control subjects (8 males and 16 females) to undergo cognitive testing and resting-state functional magnetic resonance imaging. Graph theoretical analysis of functional brain networks revealed abnormal small-world architecture in T2DM patients as compared to control subjects. The functional brain networks of T2DM patients showed increased path length, decreased global efficiency and disrupted long-distance connections. Moreover, reduced nodal characteristics were distributed in the frontal, parietal and temporal lobes, while increased nodal characteristics were distributed in the frontal, occipital lobes, and basal ganglia in the T2DM patients. The disrupted topological properties correlated with cognitive performance of T2DM patients. These findings demonstrate altered topological organization of functional brain networks in T2DM patients without mild cognitive impairment.


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