Oncotarget

Research Papers:

Clinical significance of lncRNA-ATB expression in human hepatocellular carcinoma

Se Young Jang, Gyeonghwa Kim, Soo Young Park, Yu Rim Lee, Sang Hoon Kwon, Hyeong Seok Kim, Jun Sik Yoon, Jun Seob Lee, Young-Oh Kweon, Heon Tak Ha, Jae Min Chun, Young Seok Han, Won Kee Lee, Jun Young Chang, Jung Gil Park, Byungheon Lee, Won Young Tak and Keun Hur _

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Oncotarget. 2017; 8:78588-78597. https://doi.org/10.18632/oncotarget.21094

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Abstract

Se Young Jang1,*, Gyeonghwa Kim2,*, Soo Young Park1, Yu Rim Lee1, Sang Hoon Kwon1, Hyeong Seok Kim1, Jun Sik Yoon1, Jun Seob Lee1, Young-Oh Kweon1, Heon Tak Ha3, Jae Min Chun3, Young Seok Han3, Won Kee Lee4, Jun Young Chang5, Jung Gil Park6, Byungheon Lee2, Won Young Tak1 and Keun Hur2

1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea

2Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

3Department of Surgery, Kyungpook National University School of Medicine, Daegu, Republic of Korea

4Biostatistics, Medical Research Collaboration Center in Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Republic of Korea

5Department of Neurology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea

6Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea

*These authors contributed equally to this work

Correspondence to:

Keun Hur, email: [email protected]

Won Young Tak, email: [email protected]

Keywords: hepatocellular carcinoma, long noncoding RNA ATB, survival, prognosis, epithelial mesenchymal transition

Received: June 28, 2017     Accepted: September 04, 2017     Published: September 20, 2017

ABSTRACT

Hepatocellular carcinoma (HCC) is a worldwide health problem and it is important to understand the mechanistic roles of the biomolecules involved in its pathogenesis. Long non-coding RNAs (lncRNAs) are frequently and aberrantly expressed in various human cancers and are known to play a role in cancer pathogenesis. The aim of this study was to analyze the expression of lncRNA-ATB in HCC and investigate the implications for prognoses.

In total, 100 samples of HCC tissues and their corresponding, adjacent, non-cancerous liver tissues were collected. Total RNAs were extracted and the expression levels of lncRNA-ATB were measured by qRT-PCR. The association of lncRNA expression with clinicopathological features and patient survival were then analyzed.

LncRNA-ATB was significantly upregulated in HCC tissues compared with the levels in corresponding non-cancerous tissues. Expression of lncRNA-ATB was significantly associated with portal vein thrombosis, intrahepatic or extrahepatic metastases, mUICC stage, and the BCLC stage. Large tumors (> 5 cm, HR = 3.851, 95% CI = 1.431–10.364, p = 0.008) and higher lncRNA-ATB expression (HR = 4.158, 95% CI = 1.226–14.107, p = 0.022) were the significant prognostic factors for overall survival.

With this novel evidence of the involvement of lncRNA-ATB in HCC pathogenesis and clinical features, lncRNA-ATB can be concluded to have potential as a biomarker for the prognosis of HCC and as a targeted therapy for afflicted patients.


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