Oncotarget

Meta-Analysis:

The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis

Ziheng Peng, Jinhai Jia, Wenjian Gong, Xuehan Gao, Peiru Ma, Zhucheng Jin, Yue Fan, Yanchu Li and Xiaolin Zhang _

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Oncotarget. 2017; 8:99024-99032. https://doi.org/10.18632/oncotarget.20931

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Abstract

Ziheng Peng1,*, Jinhai Jia2,*, Wenjian Gong1, Xuehan Gao1, Peiru Ma1, Zhucheng Jin1, Yue Fan1, Yanchu Li1 and Xiaolin Zhang3

1Department of School of Basic Medical Sciences, Hebei Medical University, Shi Jiazhuang 050017, China

2Department of Outpatient Clinic, Hebei Medical University, Shi Jiazhuang 050017, China

3Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang 050017, China

*These authors contributed equally to this work

Correspondence to:

Xiaolin Zhang, email: [email protected]

Keywords: gastric cancer, matrix metalloproteinase 9, meta-analysis, polymorphisms susceptibility risk

Received: April 25, 2017     Accepted: August 26, 2017     Published: September 15, 2017

ABSTRACT

Purpose: A variety of studies have observed that the single nucleotide polymorphisms (SNPs) matrix metalloproteinase-9 (MMP-9) gene may be associated with the risk of gastric cancer(GC), and a cytosine (C) to thymine (T) mutation at the -1562 site of the MMP-9 gene promoter is reported to be closely related to the susceptibility. However, because of the conflicting results of these studies, we undertook a systematic meta-analysis to assess the association between the SNPs and the risk of gastric cancer.

Materials and Methods: A computerised literature search was conducted within the databases of PubMed, EMBASE, and ISI Web of Knowledge for studies on the genetic association of MMP-9-1562C/T and gastric cancer published from 2004 to 2015. The pooled odds ratio (OR) and 95% confidence intervals (CI) were estimated for each genotype using the dominant, recessive, co-dominant, and allelic models of the matrix metalloproteinase 9.

Results: Our analysis indicated a significant association of MMP-9-1562C/T with gastric cancer (dominant model [CT+TT/CC]: OR = 1.121, 95% CI = 0.965–1.304; recessive model [CC+CT/TT]: OR = 1.663, 95% CI = 1.148–2.408; co-dominant model [TT/CC]: OR = 1.666, 95% CI = 1.127–2.461; [CT/CC]: OR = 1.078, 95% CI = 0.923–1.259; allelic model [T/C]: OR = 1.150, 95% CI =1.014–1.304).

Conclusions: Our meta-analysis results demonstrated that MMP-9-1562C/T promoter polymorphisms increase the risk of developing gastric cancer.


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