MAPK, NF&#x03BA;B, and VEGF signaling pathways regulate breast cancer liver metastasis

Xinhua Chen; Zhihong Zheng; Limin Chen; Hongyu Zheng

doi:10.18632/oncotarget.20843

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

MAPK, NFκB, and VEGF signaling pathways regulate breast cancer liver metastasis

Xinhua Chen _, Zhihong Zheng, Limin Chen and Hongyu Zheng

PDF | HTML | How to cite

Oncotarget. 2017; 8:101452-101460. https://doi.org/10.18632/oncotarget.20843

Metrics: PDF 1496 views | HTML 2023 views | ?

Abstract

Xinhua Chen1, Zhihong Zheng2, Limin Chen1 and Hongyu Zheng1

1Department of Medical Oncology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, Fujian, China

2Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China

Correspondence to:

Xinhua Chen, email: [email protected]

Keywords: breast cancer; metastasis; liver; microarray; interaction network

Received: April 23, 2017 Accepted: August 07, 2017 Published: September 12, 2017

ABSTRACT

In this study, we investigated the molecular pathways regulating breast cancer liver metastasis. We identified 48 differentially expressed genes (4 upregulated and 44 downregulated) by analyzing microarray dataset GSE62598 from Gene Expression Omnibus (GEO). We constructed a genetic interaction network with 84 nodes and 237 edges using the String consortium database. The network was reliably robust with a clustering coefficient (cc) of 0.598 and protein-protein interaction (PPI) enrichment p value of zero. Using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases, we identified MAPK, NFκB and VEGF signaling pathways as the most critical pathways regulating breast cancer liver metastasis. These results indicate that the distinct breast cancer metastatic stages, including dissemination from the primary breast tumor, transit through the vasculature, and survival and proliferation in the liver, are regulated by the MAPK, NFκB, and VEGF signaling pathways.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 20843

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

MAPK, NFκB, and VEGF signaling pathways regulate breast cancer liver metastasis

Abstract