Oncotarget

Clinical Research Papers:

A risk prediction system of postoperative hemorrhage following laparoscopy-assisted radical gastrectomy with D2 lymphadenectomy for primary gastric cancer

Xin-Sheng Xie, Jian-Xian Lin, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chang-Ming Huang _ and Chao-Hui Zheng

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Oncotarget. 2017; 8:81511-81519. https://doi.org/10.18632/oncotarget.20828

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Abstract

Xin-Sheng Xie1,2,3,4,*, Jian-Xian Lin1,2,3,4,*, Ping Li1,2,3,4, Jian-Wei Xie1,2, Jia-Bin Wang1,2,3,4, Jun Lu1,2, Qi-Yue Chen1,2, Long-Long Cao1,2, Mi Lin1,2, Ru-Hong Tu1,2, Chang-Ming Huang1,2,3,4 and Chao-Hui Zheng1,2

1Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China

2Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China

3Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China

4Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, Fujian Province, China

*These authors contributed equally to this work and share co-first authorship

Correspondence to:

Chang-Ming Huang, email: [email protected]

Chao-Hui Zheng, email: [email protected]

Keywords: gastric cancer, postoperative hemorrhage, laparoscopy, D2 lymphadenectomy, risk factor

Received: July 14, 2017     Accepted: August 27, 2017     Published: September 11, 2017

ABSTRACT

Objectives: To investigate risk factors of postoperative hemorrhage (PH) following laparoscopy-assisted radical gastrectomy (LARG) with D2 lymphadenectomy for primary gastric cancer (PGC) and to use those risk factors to develop a scoring system for risk assessment.

Materials and Methods: A total of 1789 PGC patients were enrolled in our study. We analyzed the risk factors of PH and constructed a scoring system using 75% of the cases as the experimental group and 25% of the cases as a verification group to demonstrate the effectiveness.

Results: Among these 1789 patients, 46 (2.6%) developed PH. Univariate and multivariate analysis in the experimental group indicated that having more than 41 lymph node excisions, combined organ resection, stage III tumor and postoperative digestive fistula were independent risk factors of PH. According to the independent risk factors, we constructed a scoring system to separate patients into low-risk (0–2 points) and high-risk (≥ 3 points) groups. The area under the ROC curve for this scoring system was 0.748. In the verification group, the risk of PH predicted by the scoring system was not significantly different from the actual incidence observed.

Conclusions: This scoring system could simply and effectively predict the occurrence of PH following LARG with D2 lymphadenectomy for PGC. The predictive system will help surgeons evaluate risk and select risk-adapted interventions to improve surgical safety.


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