Research Papers:
Propensity score matching analysis of the prognosis for the rare oxyphilic subtype of thyroid cancer (Hurthle cell carcinoma)
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Abstract
Yiquan Xiong1,*, Qiuyang Zhao1,*, Zhi Li1, Shuntao Wang1, Hui Guo1, Zeming Liu1 and Tao Huang1
1Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
*These authors have contributed equally to this work
Correspondence to:
Tao Huang, email: [email protected]
Zeming Liu, email: [email protected]
Keywords: oxyphilic thyroid carcinoma; prognosis; SEER; PSM
Received: July 18, 2017 Accepted: August 09, 2017 Published: September 08, 2017
ABSTRACT
There is controversy regarding the prognosis of patients with oxyphilic thyroid cancer (OXTC). The present study compared the prognoses of OXTC, papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC), in order to provide a new perspective regarding the treatment guidelines for these diseases. We evaluated data from patients with thyroid cancer who were included in the Surveillance, Epidemiology, and End Results database between 2004 and 2013. Patient mortality was evaluated using Cox proportional hazards regression analyses and Kaplan-Meier analyses with log-rank tests. The multivariate Cox regression analysis revealed that the cancer-specific survival rate for OXTC was similar to that for PTC, but higher than that for FTC. However, after propensity score matching for relevant factors, the cancer-specific survival rate for OXTC was higher than that for PTC and FTC. This unexpected result provides new implications for the treatment of patients with OXTC.
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