Association of a common genetic variant in RNASEL and prostate cancer susceptibility

Abstract

The RNASEL gene (2’, 5’-oligoisoadenylate synthetase-dependent) encodes a ribonuclease that plays a significant role in the apoptotic and antiviral activities of interferons. Various studies have used polymorphisms in the RNASEL gene to evaluate prostate cancer risk but studies that show an association between RNASEL Arg462Gln (1385G>A, R462Q, rs486907) polymorphism and prostate cancer risk are somewhat inconclusive. To assess the impact of RNASEL Arg462Gln polymorphism on prostate cancer risk, we conducted a meta-analysis of all available studies including 11,522 patients and 10,976 control subjects. The overall results indicated no positive association between the variant and prostate cancer risk. However, in a subgroup analysis by ethnicity, obvious associations were observed in Hispanic Caucasians for allelic contrast (OR = 1.18, 95% CI = 1.00 - 1.39, P_{heterogeneity} = 0.010), homozygote comparison (OR = 1.50, 95% CI = 1.02 – 2.20, P_{heterogeneity} = 0.001), and the recessive genetic model (OR = 1.44, 95% CI = 1.01 - 2.05, P_{heterogeneity} = 0.002) ; and in African descendants for homozygote comparison (OR = 2.59, 95% CI = 1.29 – 5.19, P_{heterogeneity} = 0.194) and the recessive genetic model (OR = 2.61, 95% CI = 1.30 – 5.23, P_{heterogeneity} = 0.195). In conclusion, the RNASEL Arg462Gln polymorphism may contribute to the risk of developing prostate cancer in African descendants and Hispanic Caucasians. Further larger and well-designed studies are warranted to evaluate this association in detail.