Cell-free circulating tumor DNA analysis for breast cancer and its clinical utilization as a biomarker

Ru Wang; Xiao Li; Huimin Zhang; Ke Wang; Jianjun He

doi:10.18632/oncotarget.20608

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Cell-free circulating tumor DNA analysis for breast cancer and its clinical utilization as a biomarker

Ru Wang, Xiao Li, Huimin Zhang, Ke Wang and Jianjun He _

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Oncotarget. 2017; 8:75742-75755. https://doi.org/10.18632/oncotarget.20608

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Abstract

Ru Wang1, Xiao Li1, Huimin Zhang1, Ke Wang1 and Jianjun He1

1Department of Breast Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, P.R. China

Correspondence to:

Jianjun He, email: [email protected]

Keywords: biomarker, liquid biopsy, ctDNA, breast cancer

Received: May 09, 2017 Accepted: August 17, 2017 Published: September 01, 2017

ABSTRACT

Circulating tumor DNA (ctDNA) in the blood of cancer patients contains much information on genetic and epigenetic profiles associated with cancer development, progression, and response to therapy. Analysis of ctDNA provides an opportunity for non-invasive sampling of tumor DNA repetitiously and therefore advance precision medicine. Recent development in massively parallel sequencing and digital genomic techniques support the analytical and clinical validity of ctDNA as a promising ‘liquid biopsy’ in human cancer. In this review, we discussed the current status of cell-free ctDNA including ctDNA biology, recently developed techniques for ctDNA detection, breast cancer specific detecting strategies, with a focus on clinical applications of ctDNA-based biomarkers in breast oncology.

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Cell-free circulating tumor DNA analysis for breast cancer and its clinical utilization as a biomarker

Abstract