Oncotarget

Meta-Analysis:

Association between essential hypertension and bone mineral density: a systematic review and meta-analysis

Ziliang Ye, Haili Lu and Peng Liu _

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Oncotarget. 2017; 8:68916-68927. https://doi.org/10.18632/oncotarget.20325

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Abstract

Ziliang Ye1,2, Haili Lu1 and Peng Liu3

1Guangxi Medical University, Nanning, Guangxi 530021, China

2Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China

3Department of Anatomy, Guangxi Medical University, Nanning, Guangxi 530021, China

Correspondence to:

Peng Liu, email: [email protected]

Keywords: association, essential hypertension, bone mineral density, meta-analysis

Received: May 07, 2017     Accepted: August 06, 2017     Published: August 18, 2017

ABSTRACT

Background: We conducted this systematic review and meta-analysis to evaluate the association between essential hypertension (EH) and bone mineral density (BMD).

Results: 17 articles were included in our meta-analysis, with a total of 39,491 patients. Of these, 13,375 were patients with EH and 26,116 were patients without EH. Meta-analysis results showed that EH can reduce the BMD of the lumbar spine (95% CI: −0.08~0.01, P=0.006), femoral neck (95% CI: −0.09~-0.02, p = 0.001), ward's triangle (95% CI: −0.45~-0.25, p=0.000), femoral intertrochanteric (95% CI: −0.90~-0.64, p = 0.000), calcaneus (95% CI: −0.31~-0.18, p = 0.000) and distal forearm (95% CI: −0.09~-0.03, p = 0.000), but EH cannot reduce the BMD of the femur rotor (95% CI: −0.07~0.24, p = 0.273). Subgroup analysis showed that EH can reduce the BMD of the lumbar spine (95% CI: −0.11~-0.03, p = 0.000) and femoral neck (95% CI: −0.11~-0.07, p = 0.000) in Asian populations. In non-Asian populations, EH can reduce the BMD of the femoral neck (95% CI: 0.04~0.19, p = 0.002), but cannot reduce the BMD of the lumbar spine (95% CI: −0.04~0.11, p = 0.346).

Materials and Methods: We conducted a systematic review of the published literature on the association of EH and BMD by searching the Cochrane Library, PubMed, EMBASE, CBM, CNKI and VIP databases inception to October 2016. Stata 11.0 software was used for data analysis.

Conclusions: Our meta-analysis suggests that EH can reduce the BMD of the human body, and for different parts of the bone, the degree of reduction is different. In addition, for different regions and populations, the reduction level of BMD is inconsistent.


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