A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction

Juan Li; Chun-Xia Zhang; Yi-Mei Liu; Ke-Li Chen; Gang Chen

doi:10.18632/oncotarget.20084

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction

Juan Li, Chun-Xia Zhang, Yi-Mei Liu, Ke-Li Chen and Gang Chen _

PDF | HTML | How to cite

Oncotarget. 2017; 8:65717-65729. https://doi.org/10.18632/oncotarget.20084

Metrics: PDF 2708 views | HTML 4654 views | ?

Abstract

Juan Li1, Chun-Xia Zhang1, Yi-Mei Liu1, Ke-Li Chen1 and Gang Chen1,2

1Key Laboratory of Ministry of Education on Traditional Chinese Medicine Resource and Compound Prescription, Hubei University of Chinese Medicine, Wuhan 430065, Hubei, China

2Hubei College of Chinese Medicine, Jingzhou 434020, Hubei, China

Correspondence to:

Gang Chen, email: [email protected]

Keywords: resveratrol, caloric restriction, SIRT1, aging

Received: June 12, 2017 Accepted: July 25, 2017 Published: August 09, 2017

ABSTRACT

Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated in vitro and in vivo. IMR-90 cells treated with 2,2’-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage. Moreover, they could up-regulate telomerase (TE) activity, increase expressions of SIRT1, forkhead box 3a (Foxo3a), active regulator of SIRT1 (AROS) and Hu antigen R (HuR ), but decrease p53 and deleted in breast cancer 1 (DBC1) levels. However, 10 μM resveratrol in vitro and the high dose group in vivo showed relatively stronger activities of anti-aging and stimulating SIRT1 level than CR. In conclusion, resveratrol and CR showed similar anti-aging activities on SIRT1 signaling, implicating the potential of resveratrol as a CR mimetic.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 20084

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction

Abstract