Statin use and non-melanoma skin cancer risk: a meta-analysis of randomized controlled trials and observational studies

Keming Yang; Andrew Marley; Huilin Tang; Yiqing Song; Jean Y. Tang; Jiali Han

doi:10.18632/oncotarget.20034

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Meta-Analysis:

Statin use and non-melanoma skin cancer risk: a meta-analysis of randomized controlled trials and observational studies

Keming Yang, Andrew Marley, Huilin Tang, Yiqing Song, Jean Y. Tang and Jiali Han _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:75411-75417. https://doi.org/10.18632/oncotarget.20034

Metrics: PDF 1458 views | HTML 4756 views | ?

Abstract

Keming Yang1, Andrew Marley1, Huilin Tang1, Yiqing Song1, Jean Y. Tang2 and Jiali Han1

1Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN 46202-2872, USA

2Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94063, USA

Correspondence to:

Jiali Han, email: [email protected]

Keywords: statins, non-melanoma skin cancer, meta-analysis

Received: June 26, 2017 Accepted: July 26, 2017 Published: August 08, 2017

ABSTRACT

Background: Existing evidence of the association between statin use and non-melanoma skin cancer (NMSC) risk has been inconsistent.

Objective: To maximize statistical power to synthesize prospective evidence on this relationship.

Materials and Methods: PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrial.gov were systematically searched up to December 11, 2016. A random-effects meta-analysis was conducted to calculate summary estimates.

Results: Our meta-analysis of 14 randomized controlled trials (RCTs) including 63,157 subjects showed no significant association between statin use and NMSC risk (RR = 1.09, 95%CI = 0.85–1.39). However, meta-analysis of four observational studies including 1,528,215 participants showed significantly increased risk of NMSC among statin users compared to non-users (RR = 1.11, 95%CI = 1.02–1.22). Furthermore, ever using lipophilic statins (RR = 1.14, 95%CI = 1.04–1.24) or lower-potency statins (RR = 1.14, 95%CI = 1.03–1.26), as well as usage of any statin longer than one year (RR = 1.14, 95%CI = 1.09–1.18) were significantly associated with increased NMSC risk based on observational studies.

Conclusions: Evidence from observational studies supported an association between statin use and increased NMSC risk. This finding should be interpreted with caution due to modest number of included studies, possible between-study heterogeneity and inherent limitations of observational studies.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 20034

Publication Alerts

Post-Publication Promotion

Publication Discount

Meta-Analysis:

Statin use and non-melanoma skin cancer risk: a meta-analysis of randomized controlled trials and observational studies

Abstract