Rab25 GTPase: Functional roles in cancer

Sisi Wang; Chunhong Hu; Fang Wu; Shasha He

doi:10.18632/oncotarget.19571

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Rab25 GTPase: Functional roles in cancer

Sisi Wang, Chunhong Hu, Fang Wu and Shasha He _

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Oncotarget. 2017; 8:64591-64599. https://doi.org/10.18632/oncotarget.19571

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Abstract

Sisi Wang1, Chunhong Hu1, Fang Wu1 and Shasha He1

1Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China

Correspondence to:

Shasha He, email: [email protected]

Keywords: Rab25, small GTPase, vesicle trafficking, ovarian cancer, renal cancer

Received: March 21, 2017 Accepted: July 19, 2017 Published: July 26, 2017

ABSTRACT

Rab25, a small GTPase belongs to the Rab protein family, has a pivotal role in cancer pathophysiology. Rab25 governs cell-surface receptors recycling and cellular signaling pathways activation, allowing it to control a diverse range of cellular functions, including cell proliferation, cell motility and cell death. Aberrant expression of Rab25 was linked to cancer development. Majority of research findings revealed that Rab25 is an oncogene. Elevated expression of Rab25 was correlated with poor prognosis and aggressiveness of renal, lung, breast, ovarian and other cancers. However, tumor suppressor function of Rab25 was reported in several cancers, such as colorectal cancer, indicating the tumor type-specific function of Rab25. In this review, we recapitulate the current knowledge of Rab25 in cancer development and therapy.

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Rab25 GTPase: Functional roles in cancer

Abstract