Research Papers:
Presence of Salmonella AvrA in colorectal tumor and its precursor lesions in mouse intestine and human specimens
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Abstract
Rong Lu1, Maarten Bosland2, Yinglin Xia1,3, Yong-guo Zhang1, Ikuko Kato4 and Jun Sun1
1Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
2Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA
3Division of Academic Internal Medicine and Geriatrics, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
4Department of Oncology and Pathology, Wayne State University School of Medicine, Detroit, MI, USA
Correspondence to:
Jun Sun, email: [email protected]
Ikuko Kato, email: [email protected]
Keywords: colorectal cancer, inflammation, infection, IBD, Salmonella
Received: April 19, 2017 Accepted: June 26, 2017 Published: July 06, 2017
ABSTRACT
Evidence directly supporting an association between Salmonella infection and colorectal cancer in human subjects is sparse. It has been well recognized that Salmonella infection increases the risk of gallbladder cancer. AvrA, a bacterial protein from Salmonella enterica, plays a crucial role in establishing chronic infection. To our knowledge, the presence of the bacterial AvrA has never been studied in human samples. Here, we demonstrated the presence and cellular localization of AvrA in inflamed, colorectal tumor and its precursor lesions, using both animal experimental infection models and human clinical specimens. We performed a newly developed AvrA serological assay and to determine the presence of anti-Salmonella AvrA antibody in chronic infected mouse serum samples. Further, we tested the presence of AvrA gene in healthy human fecal samples, in order to advance etiological studies of Salmonella AvrA in human population. Our study suggests a potential role of this bacterial protein in human colorectal cancer. Moreover, our new serological assay may serve a useful tool to identify individuals at increased risk for colorectal cancer.
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