Research Papers:
Association of striking life events with primary breast cancer in 265 Chinese women: a case-control study
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Abstract
Yan Lin1,*, Shengsheng Wang2,*, Xiaohui Zhang1, Changjun Wang1, Guangliang Shan3, Yidong Zhou1, Feng Mao1, Jinghong Guan1, Xin Huang1, Ying Zhong1, Qiang Sun1
1Department of Breast Disease, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China
2Physical Examination Center, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China
3Department of Epidemiology, Institute of Basic Medical Sciences, Peking Union Medical College, Beijing 100730, China
*These authors have contributed equally to this work
Correspondence to:
Qiang Sun, email: [email protected]
Keywords: breast cancer, case-control study, striking life events
Abbreviations: BMI: body mass index; CI: confidence intervals; ORs: odds ratios.
Received: November 15, 2016 Accepted: March 19, 2017 Published: June 27, 2017
ABSTRACT
The current case-control study investigated the relationship between striking life events and breast cancer in Chinese women. A total of 265 primary breast cancer patients and 265 controls were enrolled with matching for age and completed questionnaires. Logistic regression analysis was used. Thirty-nine breast cancer patients reported striking life events and twenty-four of the controls reported striking life events. The number of striking life events was significantly greater in patients (p = 0.04). It indicated a striking life event led to a 1.726-fold increased HR (95% CI 1.005-2.965, p < 0.05) for breast cancer with adjustment for age, and a 1.811-fold increased HR (95% CI 1.021 - 3.212, P < 0.05) with adjustment for age, BMI, and late age at menopause. High BMI (OR: 1.680, 95% CI: 1.258-2.196, p < 0.05) and a family history of breast cancer (OR: 2.244, 95% CI: 1.065-4.729, p < 0.05, respectively) increased the risk of breast cancer, and late age at menopause decreased the risk for breast cancer (OR: 0.513, 95% CI: 0.303-0.868, p < 0.05). Our findings indicate a significant association between striking life events and breast cancer in Chinese women, especially in the subpopulation with high BMI or family history of breast cancer.
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PII: 18744