Oncotarget

Research Papers:

IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population

Fei Wang, Yingai Zhang, Shunlan Wang, Yadong Zhang, Dinglan Wu, Chong Zhang, Yuanhui Gao, Xi Liu, Weifu Wang and Shufang Zhang _

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Oncotarget. 2017; 8:56021-56029. https://doi.org/10.18632/oncotarget.18715

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Abstract

Fei Wang1,*, Yingai Zhang2,*, Shunlan Wang2, Yadong Zhang3, Dinglan Wu4, Chong Zhang5, Yuanhui Gao2, Xi Liu2, Weifu Wang1 and Shufang Zhang2

1Department of Urology, People’s Hospital of Hainan Province, Haikou, Hainan, 570311, P.R. China

2Central Laboratory, Haikou People’s Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, Hainan, 570208, P.R. China

3Department of Urology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, P.R. China

4Central Laboratory, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, 518110, P.R. China

5Department of Urology, Haikou People’s Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, Hainan, 570208, P.R. China

*Joint first author

Correspondence to:

Shufang Zhang, email: [email protected]

Weifu Wang, email: [email protected]

Keywords: renal cell carcinoma (RCC), case-control studies, IL1, single-nucleotide polymorphism (SNP)

Received: March 06, 2017     Accepted: May 22, 2017     Published: June 28, 2017

ABSTRACT

Renal cell carcinoma (RCC) is considered a cytokine-responsive tumor. However, with the lack of diagnostic screening biomarkers, early diagnosis of RCC is challenging. Our study was investigated the association of IL1 gene polymorphisms and RCC risk. We conducted a case-control study of 291 RCC cases and 463 controls to evaluation the IL1RN of single nucleotide polymorphisms (SNPs) on RCC risk. We selection of 16 SNPs in IL1RN, IL1A, IL1B genes were analyzed. Using the chi-squared (χ2) test and genetic model analysis, we found an association with RCC risk for five SNPs [rs3783550 (IL1A), rs3783546 (IL1A), rs1609682 (IL1A), rs3783521 (IL1A), and rs1143623 (IL1B)] and increased the risk of RCC. Stratified analyses show that smoking, not drinking and age>55 populations relative to nonsmoking, drinking and age<55 more susceptible. Our study suggested that IL1B and IL1A may involve in the development of RCC in Chinese Han population.


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