The PI3K/Akt pathway: a critical player in intervertebral disc degeneration

Zhi-Hua Ouyang; Wen-Jun Wang; Yi-Guo Yan; Bin Wang; Guo-Hua Lv

doi:10.18632/oncotarget.18628

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

The PI3K/Akt pathway: a critical player in intervertebral disc degeneration

Zhi-Hua Ouyang, Wen-Jun Wang, Yi-Guo Yan, Bin Wang and Guo-Hua Lv _

PDF | HTML | How to cite

Oncotarget. 2017; 8:57870-57881. https://doi.org/10.18632/oncotarget.18628

Metrics: PDF 3223 views | HTML 4625 views | ?

Abstract

Zhi-Hua Ouyang1,2, Wen-Jun Wang2, Yi-Guo Yan2, Bing Wang1 and Guo-Hua Lv1

1Department of Spine Surgery, The 2nd Xiangya Hospital of Central South University, Changsha, China

2Department of Spine Surgery, The First Affiliated Hospital, University of South China, Hengyang, China

Correspondence to:

Guo-Hua Lv, email: [email protected]

Keywords: IDD, PI3K, Akt, PTEN, mTOR

Received: November 07, 2016 Accepted: May 10, 2017 Published: June 27, 2017

ABSTRACT

Intervertebral disc degeneration (IDD) is thought to be the primary cause of low back pain, a severe public health problem worldwide. Current therapy for IDD aims to alleviate the symptoms and does not target the underlying pathological alternations within the disc. Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway protects against IDD, which is attributed to increase of ECM content, prevention of cell apoptosis, facilitation of cell proliferation, induction or prevention of cell autophagy, alleviation of oxidative damage, and adaptation of hypoxic microenvironment. In the current review, we summarize recent progression on activation and negative regulation of the PI3K/Akt signaling pathway, and highlight its impact on IDD. Targeting this pathway could become an attractive therapeutic strategy for IDD in the near future.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 18628

Publication Alerts

Post-Publication Promotion

Publication Discount

Reviews:

The PI3K/Akt pathway: a critical player in intervertebral disc degeneration

Abstract