Oncotarget

Research Papers:

Interactions between ACYP2 genetic polymorphisms and environment factors with susceptibility to ischemic stroke in a Han Chinese Population

Qiong Cheng, Yong-Kun Li, Feng Lu, Lianhua Yin, Yin-Zhou Wang _, Wen Wei and Qian Lin

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Oncotarget. 2017; 8:97913-97919. https://doi.org/10.18632/oncotarget.18430

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Abstract

Qiong Cheng1,*, Yong-Kun Li1,*, Feng Lu2, Lianhua Yin2, Yin-Zhou Wang1, Wen Wei3 and Qian Lin4

1Department of Neurology, Fujian Provincial Hospital, Provincial Clinical Department of Fujian Medical University, Fuzhou, 350001, Fujian Province, China

2The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, 350003, Fujian Province, China

3Department of Rehabilitation of GanZhou Municipal Hospital, GanZhou, 341000, Jiangxi Province, China

4Department of Neurology, Fuzhou Second Hospital, Fuzhou, 350007, Fujian Province, China

*This author equally contributed to this work

Correspondence to:

Yin-Zhou Wang, email: [email protected]

Keywords: ischemic stroke, single nucleotide polymorphisms, interaction, smoking, alcohol drinking

Received: April 05, 2017     Accepted: May 14, 2017     Published: June 09, 2017

ABSTRACT

Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within ACYP2 gene and additional gene- environment interaction with ischemic stroke (IS) risk in a Chinese population.

Results: IS risk was significantly higher in carriers with the G allele of rs11896604 than those with CC genotype (CG or GG versus CC), adjusted OR (95%CI) =1.60 (1.18–2.20), and higher in carriers with the A allele of rs12615793 than those with GG genotype (GA or AA versus GG), adjusted OR (95%CI) = 1.66 (1.24–2.15). GMDR model shown a significant two-locus model (p = 0.0010) involving rs11896604 and alcohol drinking, and a significant two-locus model (p = 0.0010) involving rs12615793 and smoking. Current smokers with rs12615793- GA or AA genotype have the highest IS risk, compared to never- smokers with rs12615793-GG genotype, OR (95%CI) = 2.72 (1.64–3.86); current drinkers with rs11896604-CG or GG genotype have the highest IS risk, compared to never- drinkers with rs11896604-CC genotype, OR (95%CI) = 2.51 (1.70–3.40).

Materials and Methods: A total of 1202 participants (660 males, 542 females) were selected, including 600 IS patients and 602 control participants. The mean age of all participants was 68.2 ± 15.8 years. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination. Logistic regression was performed to investigate the impact of 4 SNPs within ACYP2 gene, additional gene-smoking or drinking interaction on IS risk.

Conclusions: We found that the G allele of rs11896604 and the A allele of rs12615793 within ACYP2 gene, rs12615793- smoking interaction, and rs11896604-alcohol drinking interaction were all associated with increased IS risk.


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