Oncotarget

Research Papers:

Alpha-glucosidase inhibitor use is associated with decreased colorectal neoplasia risk in patients with type 2 diabetes mellitus receiving colonoscopy: a retrospective study

Yohei Horibe, Seiji Adachi _, Tomohiko Ohno, Naoe Goto, Mitsuru Okuno, Midori Iwama, Osamu Yamauchi, Takao Kojima, Koshiro Saito, Takashi Ibuka, Ichiro Yasuda, Hiroshi Araki, Hisataka Moriwaki and Masahito Shimizu

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Oncotarget. 2017; 8:97862-97870. https://doi.org/10.18632/oncotarget.18416

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Abstract

Yohei Horibe1, Seiji Adachi1, Tomohiko Ohno1, Naoe Goto1, Mitsuru Okuno1, Midori Iwama1, Osamu Yamauchi1, Takao Kojima1, Koshiro Saito1, Takashi Ibuka2,3, Ichiro Yasuda2, Hiroshi Araki3, Hisataka Moriwaki3 and Masahito Shimizu3

1Department of Gastroenterology and Internal Medicine, Gihoku Kosei Hospital, Yamagata, 501-2105, Japan

2Division for Regional Cancer Control, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan

3Department of Gastroenterology and Internal Medicine, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan

Correspondence to:

Seiji Adachi, email: [email protected]

Keywords: type 2 diabetes mellitus, colorectal neoplasia, risk factor

Received: October 13, 2016     Accepted: May 03, 2017     Published: June 08, 2017

ABSTRACT

Purpose: The purpose of this study was to clarify the factors that influence the incidence of colorectal neoplasia in patients with type 2 diabetes mellitus (DM).

Study Design and Setting: Among a total of 1176 patients who underwent total colonoscopy at our hospital, we retrospectively analyzed 168 patients with type 2 DM. Univariate and multivariate logistic regression analyses were then performed to identify the risk factors associated with colorectal neoplasia.

Results: A multivariate analysis of these patients demonstrated that male gender (odds ratio [OR] = 4.04, 95% confidence interval [CI] = 1.67–10.37, p = 0.002), taking statins (OR = 4.59, 95% CI = 1.69–13.43, p = 0.003), taking alpha glucosidase inhibitor (α-GI) (OR = 0.35, 95% CI = 0.13–0.87, p = 0.023) and taking low-dose aspirin (LDA) (OR = 0.32, 95% CI = 0.10–0.95, p = 0.040) were independent factors associated with an increased (male gender and statins) or decreased (α-GI and LDA) risk of colorectal neoplasia.

Conclusions: While male gender and taking statins are risk factors, taking α-GI as well as LDA may reduce the risk of colorectal neoplasia in patients with type2 DM.


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