Preclinical evidence of ghrelin as a therapeutic target in epilepsy

Tongtong Ge; Wei Yang; Jie Fan; Bingjin Li

doi:10.18632/oncotarget.18349

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Preclinical evidence of ghrelin as a therapeutic target in epilepsy

Tongtong Ge, Wei Yang, Jie Fan and Bingjin Li _

PDF | HTML | How to cite

Oncotarget. 2017; 8:59929-59939. https://doi.org/10.18632/oncotarget.18349

Metrics: PDF 2124 views | HTML 3426 views | ?

Abstract

Tongtong Ge1,*, Wei Yang1,*, Jie Fan1 and Bingjin Li1

1Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, PR China

*These authors contributed equally to this work

Correspondence to:

Bingjin Li, email: [email protected]

Keywords: ghrelin, epilepsy, hippocampus, memory, neuroprotection

Received: March 08, 2017 Accepted: May 22, 2017 Published: June 02, 2017

ABSTRACT

Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, plays a major role in inhibiting seizures. However, the underlying mechanism of ghrelin’s anticonvulsant action is still unclear. Nowadays, there are considerable evidences showing that ghrelin is implicated in various neurophysiological processes, including learning and memory, neuroprotection, neurogenesis, and inflammatory effects. In this review, we will summarize the effects of ghrelin on epilepsy. It may provide a comprehensive picture of the role of ghrelin in epilepsy.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 18349

Publication Alerts

Post-Publication Promotion

Publication Discount

Reviews:

Preclinical evidence of ghrelin as a therapeutic target in epilepsy

Abstract