Research Papers:
LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma
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Abstract
Jiangfeng Hu1,*, Chenlin Song2,*, Bensong Duan1,*, Xiaoyan Zhang3, Dongliang Li4, Liang Zhu5 and Hengjun Gao6,7
1Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China
2Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany
3Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai, Shanghai, China
4Department of Hepatobiliary Medicine, Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou, China
5Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China
6National Engineering Center for Biochip at Shanghai, Shanghai, China
7Department of Gastroenterology, Institute of Digestive Diseases, Tongji University School of Medicine, Shanghai, China
*These authors contributed equally to this work
Correspondence to:
Hengjun Gao, email: [email protected]
Dongliang Li, email: [email protected]
Liang Zhu, email: [email protected]
Keywords: lncRNA-SVUGP2, hepatocellular carcinoma, proliferation, invasion, liver
Received: March 06, 2017 Accepted: April 25, 2017 Published: May 29, 2017
ABSTRACT
Numerous studies indicate that long noncoding RNAs (lncRNAs) are dysregulated in hepatocellular carcinoma (HCC) and might serve as potential diagnostic biomarkers and therapeutic targets of HCC. Therefore, it is interesting to globally identify the lncRNAs altered in HCC. In our study, we used microarray to profile the levels of lncRNAs and mRNAs in three pairs of HCC and their adjacent noncancerous samples. We found lncRNA-SVUGP2, which is a splice variant of the UGP2 gene, was down-regulated in HCC samples and correlates with a better prognosis in patients with HCC. Overexpression of lncRNA-SVUGP2 in HepG2 and Hep3B liver cancer cells suppresses cell proliferation in vitro and tumor growth in vivo. Moreover, lncRNA-SVUGP2 suppresses the invasion ability of liver cancer cell lines and downregulates the mRNA and protein levels of MMP2 and 9. Additionally, lncRNA-SVUGP2 positively or negatively correlates with many mRNAs in liver cancer tissues, indicating it is multifunctional in regulating carcinogenesis.
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