Oncotarget

Research Papers:

Phylogenic analysis and forensic genetic characterization of Chinese Uyghur group via autosomal multi STR markers

Xiaoye Jin, Yuanyuan Wei, Jiangang Chen, Tingting Kong, Yuling Mu, Yuxin Guo, Qian Dong, Tong Xie, Haotian Meng, Meng Zhang, Jianfei Li, Xiaopeng Li _ and Bofeng Zhu

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Oncotarget. 2017; 8:73837-73845. https://doi.org/10.18632/oncotarget.17992

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Abstract

Xiaoye Jin1,2,3,*, Yuanyuan Wei1,2, Jiangang Chen4, Tingting Kong1,2, Yuling Mu1,2,3, Yuxin Guo1,2,3, Qian Dong1,2,3, Tong Xie5, Haotian Meng1,2, Meng Zhang6, Jianfei Li7, Xiaopeng Li8 and Bofeng Zhu1,2,5,*

1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, PR China

2Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, PR China

3College of Medicine and Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, PR China

4Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, PR China

5Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, PR China

6Department of Orthopaedics, Ankang City Central Hospital, Ankang, 725000, Shaanxi, PR China

7Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, PR China

8Department of Ultrasound, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, PR China

*These authors contributed equally to this work

Correspondence to:

Xiaopeng Li, email: [email protected]

Keywords: short tandem repeats (STRs), inter-population differentiation, Uyghur ethnic group, phylogenic analysis, PCA

Received: March 28, 2017     Accepted: May 06, 2017     Published: May 18, 2017

ABSTRACT

We investigated the allelic frequencies and forensic descriptive parameters of 23 autosomal short tandem repeat loci in a randomly selected sample of 1218 unrelated healthy Uyghur individuals residing in the Xinjiang Uyghur Autonomous Region, northwest China. A total of 281 alleles at these loci were identified and their corresponding allelic frequencies ranged from 0.0004 to 0.5390. The combined match probability and combined probability of exclusion of all loci were 5.192 × 10–29 and 0.9999999996594, respectively. The results of population genetic study manifested that Uyghur had close relationships with those contiguous populations, such as Xibe and Hui groups. In a word, these autosomal short tandem repeat loci were highly informative in Uyghur group and the multiplex PCR system could be used as a valuable tool for forensic caseworks and population genetic analysis.


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