Increased CCL19 expression is associated with progression in cervical cancer

Xiaoshu Zhang; Yue Wang; Yanning Cao; Xueshan Zhang; Haiya Zhao

doi:10.18632/oncotarget.17982

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Increased CCL19 expression is associated with progression in cervical cancer

Xiaoshu Zhang _, Yue Wang, Yanning Cao, Xueshan Zhang and Haiya Zhao

PDF | HTML | How to cite

Oncotarget. 2017; 8:73817-73825. https://doi.org/10.18632/oncotarget.17982

Metrics: PDF 1998 views | HTML 3052 views | ?

Abstract

Xiaoshu Zhang1, Yue Wang1, Yanning Cao1, Xueshan Zhang1 and Haiya Zhao1

1Department of Immunology, Binzhou Medical University, Yantai, 264003, China

Correspondence to:

Xiaoshu Zhang, email: [email protected]

Keywords: cervical cancer, CCL19, EMT, invasion, proliferation

Received: December 20, 2016 Accepted: April 26, 2017 Published: May 18, 2017

ABSTRACT

Cervical cancer is the third most common cancer and the fourth leading cause of malignancy related mortality in women worldwide. CCL19 is highly expressed in human cancer cells, and ligand CCL19 binding to CCR7 induces actin polymerization and pseudopodia formation. However, whether or not CCL19 is involved in EMT of human cervical cancer needs further investigation. Using quantitative PCR and western blot analyses, we found that CCL19 is overexpressed in cervical cancer cell lines and tissues. Knockdown of CCL19 via siRNA inhibited the proliferation of cervical cancer cells by increasing apoptosis. Further analyses showed that inhibitory effects of CCL19 on cell migration and invasion were partly associated with EMT process. In conclusion, these data indicate that CCL19 is abnormally expressed in cervical cancer, indicating a novel and important role for CCL19 in cervical cancer malignant transformation.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 17982

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

Increased CCL19 expression is associated with progression in cervical cancer

Abstract