Oncotarget

Clinical Research Papers:

Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer’s disease

Yu Sun, Yafei Wang, Jiaming Lu, Rengyuan Liu, Christopher G. Schwarz, Hui Zhao, Yue Zhang, Lingyi Xu, Bin Zhu, Bing Zhang _, Bing Liu, Suiren Wan and Yun Xu

PDF  |  HTML  |  How to cite

Oncotarget. 2017; 8:99112-99124. https://doi.org/10.18632/oncotarget.17944

Metrics: PDF 2091 views  |   HTML 2796 views  |   ?  


Abstract

Yu Sun1,2,*, Yafei Wang1,*, Jiaming Lu3,*, Rengyuan Liu4, Christopher G. Schwarz5, Hui Zhao4, Yue Zhang1, Lingyi Xu1, Bin Zhu3, Bing Zhang3, Bing Liu6, Suiren Wan1 and Yun Xu4

1School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China

2The Institute of Cancer and Genomics Sciences, University of Birmingham, Birmingham, U.K.

3Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

4Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

5Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA

6Brainnetome Center, Institute of Automation, Chinese Academy of Science, Beijing, China

*These authors have contributed equally to this work

Correspondence to:

Bing Zhang, email: [email protected]

Keywords: functional connectivity; perirhinal cortex; parahippocampal cortex; AD; MCI

Received: November 14, 2016     Accepted: March 06, 2017     Published: May 16, 2017

ABSTRACT

Most patients with mild cognitive impairment and Alzheimer’s disease can initially present memory loss. The medial temporal lobes are the brain regions most associated with declarative memory function. As sub-components of the MTL, the perirhinal cortex, parahippocampal cortex and hippocampus have also been identified as playing important roles in memory. The functional connectivity between hippocampus subfields and perirhnial cortices as well as parahippocampal cortices among normal cognition controls (NC group, n=33), mild cognitive impairment (MCI group, n=31) and Alzheimer’s disease (AD group, n=27) was investigated in this study. The result shows significant differences of functional connectivity in 3 pairs of regions among NC group, MCI group and AD group: right perirhinal cortex with right hippocampus tail, left perirhinal cortex with right hippocampus tail, and right parahippocampal cortex with right hippocampus head. Clustering methods were used to classify NC group, MCI group and AD group (accuracy=100%) as well as different subtypes of mild cognitive impairment patients based on functional alterations. Functional connectivity disrupted between perirhinal and parahippocampal cortex with hippocampal subfields, which may provide a better understanding of the neurodegenerative progress of MCI and AD.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 17944