Oncotarget

Research Papers:

Preoperative transcatheter arterial chemotherapy may suppress oxidative stress in hepatocellular carcinoma cells and reduce the risk of short-term relapse

Hao Su, Guangzhi Zhu, Ketut Indra Djaja P, Yi Lin, Yizhen Gong, Xiaoguang Liu, Jiaquan Li, Zhiming Liu, Xiao Qin, Lequn Li, Tangwei Liu, Zili Lu, Minyi Wei, Lunan Yan, Cheryl Ann Winkler, Stephen J. O'Brien, Jing Li, Kaiyin Xiao and Tao Peng _

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Oncotarget. 2017; 8:54402-54415. https://doi.org/10.18632/oncotarget.17660

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Abstract

Hao Su1,*, Guangzhi Zhu1,*, Ketut Indra Djaja P1,*, Yi Lin1, Yizhen Gong1, Xiaoguang Liu1, Jiaquan Li2, Zhiming Liu1, Xiao Qin1, Lequn Li1, Tangwei Liu1, Zili Lu3, Minyi Wei3, Lunan Yan4, Cheryl Ann Winkler5, Stephen J. O’Brien5, Jing Li6, Kaiyin Xiao1 and Tao Peng1,5

1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China

2Experimental Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China

3Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China

4Department of General Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan Province, China

5Laboratory of Genomic Diversity, National Cancer Institute, National Institutes of Health, Frederick, MD 21702-1201, USA

6Department of Physiology and Pathophysiology, College of Basic Medical Science, Peking University, Health Science Center, Beijing, 100191, China

*These authors contributed equally to this work

Correspondence to:

Tao Peng, email: [email protected]

Kaiyin Xiao, email: [email protected]

Keywords: transcatheter arterial chemotherapy, hepatocellular carcinoma, TP53, p21waf1/cip1, oxidative stress

Received: August 12, 2016     Accepted: April 21, 2017     Published: May 07, 2017

ABSTRACT

In this study, we aim to investigate oxidative stress in hepatocellular carcinoma (HCC) tissues in patients receiving preoperative transcatheter arterial chemotherapy (TAC) and its association with prognosis. A total of 89 HCC patients enrolled in this study, 39 received preoperative TAC 1 week before surgery (pTAC group) and 50 did not (non-pTAC group). All patients underwent hepatectomy and postoperative TAC and were followed up to 400 weeks. Samples of liver tissue without HCC and hepatitis (n = 15) served as normal controls. Cellular levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), TP53, and p21waf1/cip1 were measured in both cancer and surrounding tissues using an immunohistochemistry assay. Taken together, our data suggested that preoperative TAC might postpone postoperative HCC relapse within 1 year via suppression of tumor cells by induction of high levels of oxidative stress.


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