Do histological variants in urothelial carcinoma of the bladder portend poor prognosis? A systematic review and meta-analysis

Qingke Chen; Lei Li; Gongxian Wang; Jieping Hu; Ting Sun; Bin Fu

doi:10.18632/oncotarget.17593

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Do histological variants in urothelial carcinoma of the bladder portend poor prognosis? A systematic review and meta-analysis

Qingke Chen, Lei Li, Gongxian Wang, Jieping Hu, Ting Sun and Bin Fu _

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Oncotarget. 2017; 8:48263-48271. https://doi.org/10.18632/oncotarget.17593

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Abstract

Qingke Chen1,*, Lei Li2,*, Gongxian Wang1, Jieping Hu1, Ting Sun1 and Bin Fu1

1Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China

2Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China

*These authors contributed equally to this work

Correspondence to:

Bin Fu, email: [email protected]

Ting Sun, email: [email protected]

Jieping Hu, email: [email protected]

Keywords: histological variants, squamous differentiation, urothelial carcinoma of the bladder, prognosis

Received: November 16, 2016 Accepted: April 18, 2017 Published: May 03, 2017

ABSTRACT

The clinical implications of histological variants in urothelial carcinoma of the bladder has been a subject of significant controversy with many unanswered questions that remain. To clarify whether histological variants presage poor prognosis for patients suffering from urothelial carcinoma of the bladder, we scoured through various electronic databases such as Medline, Web of Knowledge, and the Cochrane Library up to August 18, 2016. Experts were consulted, and references from relevant articles were scanned. We identified thirteen eligible studies which met the inclusion criteria, including 9,533 participants. The existing evidence indicates that histological variants in urothelial carcinoma of the bladder patients do not alter their prognosis.

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Do histological variants in urothelial carcinoma of the bladder portend poor prognosis? A systematic review and meta-analysis

Abstract