Oncotarget

Research Papers:

Variants in the CXCL12 gene was associated with coronary artery disease susceptibility in Chinese Han population

Junbo Zhang, Huijun Ma, Jie Gao, Shu Kong, Jiangtao You and Ying Sheng _

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Oncotarget. 2017; 8:54518-54527. https://doi.org/10.18632/oncotarget.17171

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Abstract

Junbo Zhang1,*, Huijun Ma2,*, Jie Gao3, Shu Kong4, Jiangtao You5 and Ying Sheng1

1Department of Peripheral Vascular, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

2Department of Cardiology, The First Hospital of Xi’an, Xi’an 710002, China

3Cadre Ward of the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China

4Institute of Medical Engineering, Medical School of Xi’an Jiaotong University, Xi’an 710061, China

5Department of Thoracic Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

*Junbo Zhang and Huijun Ma contributed equally to this paper

Correspondence to:

Ying Sheng, email: [email protected]

Keywords: CXCL12, coronary heart disease, gene polymorphisms, case-control study

Received: November 01, 2016     Accepted: February 28, 2017     Published: April 18, 2017

ABSTRACT

Background: Coronary artery disease (CAD) is one of the most serious diseases all around the world. Previous studies have shown the function of CXCL12 in the process of atherosclerosis. The aim of this research is to examine whether variants of CXCL12 contribute to CAD.

Materials and Methods: To examine whether variants of CXCL12 contribute to CAD, we selected 6 single nucleotide polymorphisms (SNPs) of CXCL12, and genotyped by Sequenom MassARRAY technology in 597 CAD patients and 685 healthy control. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for age and gender. We also analysis the differences in continuous variables among the subjects with three genotypes of related genes were assessed using the ANOVA.

Results: We found significant differences in apoB concentrations with rs1065297 and rs10793538 different genotype. In the allele model, rs1065297, rs266089 and rs10793538 in CXCL12 gene associated with the risk of CAD. Stratified according to gender, rs266089 and rs2839693 in CXCL12 gene were associated with the risk of CAD in men, while rs1065297 and rs10793538 in CXCL12 gene were associated with the risk of CAD in women. Stratified according to age, rs197452 decreased the risk of CAD in less than 50 years old group. While in more than 50 years old group, not find significant results. Haplotype analysis shown that haplotype “TGCC” in the block increased CAD risk (OR=1.26, 95%CI: 1.00-1.58, p=0.046).

Conclusion: This study provides an evidence for polymorphism of CXCL12 gene associated with CAD development in Chinese Han population.


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