Oncotarget

Research Papers:

Erectile dysfunction and the risk of prostate cancer

Wei-Yu Lin, Ying-Hsu Chang, Cheng-Li Lin, Chia-Hung Kao and Hsi-Chin Wu _

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Oncotarget. 2017; 8:52690-52698. https://doi.org/10.18632/oncotarget.17082

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Abstract

Wei-Yu Lin1,2,3, Ying-Hsu Chang4, Cheng-Li Lin5,6, Chia-Hung Kao7,8,9 and Hsi-Chin Wu10,11

1Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Gia-Yi, Taiwan

2Chang Gung University of Science and Technology, Chia-Yi, Taiwan

3Department of Medicine, Chang Gung University, Taoyuan, Taiwan

4Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, LinKo, Taiwan

5Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

6School of Medicine, China Medical University, Taichung, Taiwan

7Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan

8Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan

9Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan

10Department of Urology, China Medical University Hospital, Taichung, Taiwan

11Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

Correspondence to:

Hsi-Chin Wu, email: [email protected]

Keywords: Prostate cancer (PCa), erectile dysfunction (ED), Cohort study, National Health Insurance Research Database, malignancy

Received: October 19, 2016    Accepted: March 21, 2017    Published: April 13, 2017

ABSTRACT

Background: Prostate cancer (PCa) is the most commonly diagnosed malignancy and the third leading cause of cancer death among men in developed countries. Because some risk factors are common between erectile dysfunction (ED) and PCa, we investigated the association between ED and subsequent PCa.

Methods: This nationwide population-based cohort study used data from the Taiwan National Health Insurance Research Database for the period 2000–2010. We identified patients newly diagnosed with ED by using codes from the International Classification of Diseases, Ninth Revision, Clinical Modification.

Results: In total, 5858 and 23432 patients were enrolled in the ED and non-ED cohorts, respectively. After adjustment for age, sex, and comorbidities, the overall incidence densities of PCa were significantly higher in the ED cohort than in the non-ED cohort, with an adjusted hazard ratio (aHR) of 1.19. The age-specific relative risk of PCa was significantly higher for all age groups in the ED cohort than in the non-ED cohort. Compared with patients without ED, those with organic ED had a 1.27-fold higher risk of PCa.

Conclusion: ED is a harbinger of PCa in some men. Physicians should consider the possibility of occult PCa in patients with ED regardless of age and comorbidities.


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