Oncotarget

Research Papers:

Association between genetic variants and esophageal cancer risk

Chenli Yue, Miao Li, Chenxing Da, Hongtao Meng, Shaomin Lv and Xinhan Zhao _

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Oncotarget. 2017; 8:47167-47174. https://doi.org/10.18632/oncotarget.17006

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Abstract

Chenli Yue1,2,*, Miao Li3,*, Chenxing Da4, Hongtao Meng5, Shaomin Lv2 and Xinhan Zhao1

1Department of Internal Medicine Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China

2Department of Respiratory Medicine, Shaanxi Provincial Crops Hospital of Chinese People’s Armed Police Force, Xi’an, Shaanxi 710054, China

3Department of Internal Medicine Oncology, The Fifth People’s Hospital of Qinghai Province, Xining, Qinghai 810007, China

4Department of Gastroenterology, Shaanxi Provincial Crops Hospital of Chinese People’s Armed Police Force, Xi’an, Shaanxi 710054, China

5Medical Department, Shaanxi Provincial Crops Hospital of Chinese People’s Armed Police Force, Xi’an, Shaanxi 710054, China

*These authors have contributed equally to this work

Correspondence to:

Xinhan Zhao, email: [email protected]

Keywords: esophageal cancer, genetic polymorphism, NAF1, han chinese, case-control

Received: October 27, 2016     Accepted: February 17, 2017     Published: April 10, 2017

ABSTRACT

We investigated whether single nucleotide polymorphisms (SNPs) in the nuclear assembly factor 1 (NAF1) and TNFAIP3-interacting protein 1 (TNIP1) gene were associated with susceptibility to esophageal cancer in a Chinese Han population. Five SNPs were genotyped and their relationship with esophageal cancer risk was analyzed in a sample of 386 esophageal cancer patients and 495 unrelated healthy controls recruited from the First Affiliated Hospital of Xi’an Jiaotong University. Patients with the AG genotype of rs2320615 were at lower risk of developing esophageal cancer than those with the GG genotype (adjusted odds ratio [OR] = 0.64, 95% confidence interval [CI] = 0.46-0.90, P = 0.009). The rs2320615 SNP was found to be associated with a decreased the risk of esophageal cancer in the dominant model (adjusted OR = 0.70, 95% CI = 0.51-0.96, P = 0.026). These results provide the first evidence that the rs2320615 in NAF1 was associated with reduced risk of esophageal cancer. Further studies with larger samples are warranted to confirm our findings.


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