Oncotarget

Reviews:

Micrornas in prostate cancer: an overview

Daniela Vanacore, Mariarosaria Boccellino, Sabrina Rossetti, Carla Cavaliere, Carmine D’Aniello, Rossella Di Franco, Francesco Jacopo Romano, Micaela Montanari, Elvira La Mantia, Raffaele Piscitelli, Flavia Nocerino, Francesca Cappuccio, Giovanni Grimaldi, Alessandro Izzo, Luigi Castaldo, Maria Filomena Pepe, Maria Gabriella Malzone, Gelsomina Iovane, Gianluca Ametrano, Paola Stiuso, Lucio Quagliuolo, Daniela Barberio, Sisto Perdonà, Paolo Muto, Maurizio Montella, Piera Maiolino, Bianca Maria Veneziani, Gerardo Botti, Michele Caraglia _ and Gaetano Facchini

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Oncotarget. 2017; 8:50240-50251. https://doi.org/10.18632/oncotarget.16933

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Abstract

Daniela Vanacore1,2,*, Mariarosaria Boccellino2,*, Sabrina Rossetti1,3, Carla Cavaliere1,4, Carmine D’Aniello1,5, Rossella Di Franco1,6, Francesco Jacopo Romano1, Micaela Montanari1,7, Elvira La Mantia1,8, Raffaele Piscitelli1,9, Flavia Nocerino1,10, Francesca Cappuccio1,11, Giovanni Grimaldi1,12, Alessandro Izzo1,12, Luigi Castaldo1,12, Maria Filomena Pepe1,8, Maria Gabriella Malzone1,8, Gelsomina Iovane3, Gianluca Ametrano1,6, Paola Stiuso2, Lucio Quagliuolo2, Daniela Barberio1,11, Sisto Perdonà12, Paolo Muto6, Maurizio Montella10, Piera Maiolino9, Bianca Maria Veneziani7, Gerardo Botti8,13, Michele Caraglia2 and Gaetano Facchini1,3

1Progetto ONCONET2.0, Linea progettuale 14 per l’implementazione della Prevenzione e Diagnosi Precoce del Tumore alla Prostata e Testicolo, Regione Campania, Italy

2Department of Biochemistry, Biophysics and General Pathology, University of Campania “L. Vanvitelli” Naples, Naples, Italy

3Division of Medical Oncology, Department of Uro-Gynaecological Oncology, Istituto Nazionale Tumori ‘Fondazione G. Pascale’, IRCCS, Naples, Italy

4Department of Onco-Ematology Medical Oncology, S.G. Moscati Hospital of Taranto, Taranto, Italy

5Division of Medical Oncology, A.O.R.N. dei COLLI “Ospedali Monaldi-Cotugno-CTO”, Napoli, Italy

6Radiation Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale’, IRCCS, Napoli, Italy

7Department of Molecular Medicine and Medical Biotechnologies, University of Naples “Federico II”, Naples, Italy

8Pathology Unit, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy

9Pharmacy Unit, Istituto Nazionale Tumori, Istituto Nazionale Tumori-Fondazione G. Pascale, Naples, Italy

10Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale’, IRCCS, Napoli, Italy

11Psicology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale’, IRCCS, Napoli, Italy

12Division of Urology, Department of Uro-Gynaecological Oncology, Istituto Nazionale Tumori ‘Fondazione G. Pascale’, IRCCS, Naples, Italy

13Scientific Directorate, Istituto Nazionale Tumori ‘Fondazione G. Pascale’, IRCCS, Naples, Italy

*These authors have contributed equally to this work

Correspondence to:

Michele Caraglia, email: [email protected], [email protected]

Keywords: microRNAs, prostate cancer, biomarkers, oncogenic miRNAs, tumor suppressor miRNAs

Received: February 06, 2017     Accepted: March 25, 2017     Published: April 07, 2017

ABSTRACT

Prostate cancer is the second highest cause of cancer mortality after lung tumours. In USA it affects about 2.8 million men and the incidence increases with age in many countries. Therefore, early diagnosis is a very important step for patient clinical evaluation and for a selective and efficient therapy. The study of miRNAs’ functions and molecular mechanisms has brought new knowledge in biological processes of cancer. In prostate cancer there is a deregulation of several miRNAs that may function as tumour suppressors or oncogenes. The aim of this review is to analyze the progress made to our understanding of the role of miRNA dysregulation in prostate cancer tumourigenesis.


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PII: 16933