Oncotarget

Research Papers:

The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma

Hua-Tao Wu _, Jing Liu, Guan-Wu Li, Jia-Xin Shen and Yi-Teng Huang

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Oncotarget. 2017; 8:36279-36288. https://doi.org/10.18632/oncotarget.16748

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Abstract

Hua-Tao Wu1, Jing Liu1,2, Guan-Wu Li3, Jia-Xin Shen4, Yi-Teng Huang5

1Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China

2Chang Jiang Scholar’s Laboratory, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Shantou University Medical College, Shantou, PR China

3Open Laboratory for Tumor Molecular Biology, Department of Biochemistry, The Key Lab of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, PR China

4Department of Hematology, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China

5Health Care Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China

Correspondence to:

Hua-Tao Wu, email: [email protected]

Jing Liu, email: [email protected]

Keywords: STAT, breast carcinoma, prognosis, Kaplan-Meier plot, transcription

Received: December 08, 2016     Accepted: March 21, 2017     Published: March 31, 2017

ABSTRACT

Signal Transducer and Activators of Transcription (STAT) is a set of transcription factors, involved in diverse cellular functions. Evidences from cell lines, mouse models and human tissues implicate these transcription factors in the oncogenesis of breast cancer. However, the diverse expression patterns and prognostic values of 7 STATs remain to be elucidated. In the current study, we mined the transcriptional and survival data of STATs in patients with breast carcinoma (BC) through ONCOMINE, bc-GenExMiner, Kaplan-Meier Plotter and cBioPortal. It was found that STAT1/2 were up-regulated, whereas STAT3/4/5A/5B were down-regulated in BC patients compared with the normal tissues. The expressions of STAT5A/5B/6 were correlated with decreased levels of histological differentiation. In survival analyses through the Kaplan-Meier plotter database, high transcription levels of STAT2/4/5A/5B/6 were associated with better relapse-free survival (RFS) in all BC patients. Conversely, high STAT3 predicted shorter RFS in BC patients, suggesting that STAT3 is potential targets for precision therapy to BC patients. These data also provided STAT5A/5B/6 as new biomarker for BC prognosis.


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