Oncotarget

Clinical Research Papers:

Surgical resection for hepatic metastasis from gastric cancer: a multi-institution study

Ailin Song, Xiaofeng Zhang, Feng Yu, Debang Li, Wenyu Shao and Yanming Zhou _

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Oncotarget. 2017; 8:71147-71153. https://doi.org/10.18632/oncotarget.16705

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Abstract

Ailin Song1, Xiaofeng Zhang2, Feng Yu3, Debang Li4, Wenyu Shao5 and Yanming Zhou6

1Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, China

2Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China

3Department of Hepatobiliary Surgery, the 101th Hospital of Chinese PLA, Wuxi, China

4Department of General Surgery, First Hospital of Lanzhou University, Lanzhou, China

5Department of Liver Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

6Department of Hepatobiliary and Pancreatovascular Surgery, First Affiliated Hospital of Xiamen University, Xiamen, China

Correspondence to:

Yanming Zhou, email: [email protected]

Keywords: gastric cancer, liver metastases, hepatectomy, prognosis

Received: January 02, 2017     Accepted: March 21, 2017     Published: March 30, 2017

ABSTRACT

Background: The beneficial effect of surgical resection for hepatic metastasis from gastric cancer (HMGC) remains elusive. This study was conducted to analyze surgical outcomes of HMGC and determine the prognostic factors associated with survival.

Results: The in-hospital mortality rate was zero, and the overall morbidity rate was 56%. The overall 1-, 3-, and 5-year survival rate after surgery was 87.5%, 47.6%, and 21.7%, respectively, with a median survival time of 34.0 months. Multiple liver metastases (hazard ratio [HR] =1.998; 95% confidence interval [CI] = 1.248-3.198; P = 0.004) and ≥ T3 stage of the primary gastric cancer (HR = 2.065; 95% CI = 1.201–3.549; P = 0.009) were independent prognostic determinants in the multivariate analysis.

Materials and Methods: Data on surgical resection of 96 patients with HMGC at six institutions in China were analysed retrospectively. Prognostic factors were assessed by multiple stepwise regression analysis using the Cox model.

Conclusions: Surgical resection for HMGC is feasible and beneficial to long-term survival in selected patients.


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