Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation

Xia Chen; Rui Wu; Yiwei Kong; Yuting Yang; Yu Gao; Dandan Sun; Qizhen Liu; Dongjun Dai; Zeyuan Lu; Niansong Wang; Sheng Ge; Feng Wang

doi:10.18632/oncotarget.16651

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation

Xia Chen, Rui Wu, Yiwei Kong, Yuting Yang, Yu Gao, Dandan Sun, Qizhen Liu, Dongjun Dai, Zeyuan Lu, Niansong Wang, Sheng Ge and Feng Wang _

PDF | HTML | How to cite

Oncotarget. 2017; 8:31915-31922. https://doi.org/10.18632/oncotarget.16651

Metrics: PDF 2697 views | HTML 3579 views | ?

Abstract

Xia Chen1,*, Rui Wu1,*, Yiwei Kong1,*, Yuting Yang1,*, Yu Gao1, Dandan Sun1, Qizhen Liu1, Dongjun Dai1, Zeyuan Lu1, Niansong Wang1, Sheng Ge3, Feng Wang1,2

1Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

2Department of Nephrology, Shanghai Eighth People’s Hospital, Shanghai 200233, China

3Department of Clinical Nutrition, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

*These authors contributed equally to this work

Correspondence to:

Sheng Ge, email: [email protected]

Feng Wang, email: [email protected]

Keywords: tanshinone, kidney, diabetes

Received: January 25, 2017 Accepted: March 02, 2017 Published: March 29, 2017

ABSTRACT

Oxidative stress and inflammation have been demonstrated to be involved in the onset and promotion of diabetic nephropathy (DN).Tanshinone IIA (Tan) possesses both antioxidant and anti-inflammatory properties. Here, the aim of the present study was to explore whether Tan could attenuate renal damage in the rats with streptozotocin (STZ)-induced diabetes and its potential mechanisms. Tan was gavaged to STZ-induced diabetic rats at the dose of 10mg/kg once a day for 12 weeks. Tan treatment significantly attenuated albuminuria and renal histopathology in diabetic rats. Besides, Tan treatment also effectively inhibited oxidative stress and inflammatory reaction in the kidneys of diabetic rats. Our study provided evidence that the protective effect of Tan on diabetes-induced renal injury is associated with inhibition of oxidative stress and inflammation. Tan may be a potential candidate for the treatment of DN.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 16651

Publication Alerts

Post-Publication Promotion

Research Papers:

Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation

Abstract