Research Papers:
Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma
PDF | HTML | Supplementary Files | How to cite | Press Release
Metrics: PDF 2978 views | HTML 3987 views | ?
Abstract
Yongchen Guo1,*, Yonghua Bao1,*, Ming Ma2, Shanshan Zhang3, Yongmeng Zhang3, Ming Yuan3, Bing Liu1, Yiqiong Yang1, Wen Cui1, Emmanuel Ansong4, Huali Dong4, Virgilia Macias4, Wancai Yang1,4
1Department of Pathology and Institute of Precision Medicine, Jining Medical University, Jining 272067, China
2Department of Thoracic Surgery, Affiliated Hospital, Jining Medical University, Jining 272067, China
3Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China
4Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA
*These authors contributed equally to this work
Correspondence to:
Wancai Yang, email: [email protected]
Keywords: esophagitis, Barrett's esophagus, squamous cell carcinoma, adenocarcinoma, PLCE1
Received: February 04, 2017 Accepted: March 11, 2017 Published: March 28, 2017
ABSTRACT
Esophagitis and Barrett's esophagus are linked to esophageal squamous cell carcinoma and adenocarcinoma, respectively. However, the underlying mechanisms are still unclear. This study analyzed the expression levels of and correlation between PLCE1 and PRKCA in human esophagitis, carcinogen NMBA-induced rat esophagus, PLCE1 genetic deficient mouse esophageal epithelial tissues and human esophageal cancer cell line, integrated with Online oncology data sets. We found that the expression levels of both PLCE1 and PRKCA were significantly elevated in human esophagitis, esophageal squamous cell carcinoma, Barrett's esophagus, esophageal adenocarcinoma and in NMBA-treated rat esophageal epithelia. However, PRKCA and cytokines were significantly downregulated in PLCE1-deficient mouse esophageal epithelia, and knockdown of PLCE1 in human esophageal cancer cells led to reduction of PRKCA and cytokines. Finally, high expression of both PLCE1 and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers. In conclusion, this study defined the initiation and progression of esophageal inflammation and malignant transformation, in which the positive correlation of PLCE1 and PRKCA exhibits critical clinical significance.
![Creative Commons License](/images/80x15.png)
PII: 16635