Research Papers:
A(H1N1)pdm09 influenza infection: vaccine inefficiency
Metrics: PDF 2387 views | HTML 3668 views | ?
Abstract
Nehemya Friedman1,2,*, Yaron Drori1,2,*, Rakefet Pando3, Aharona Glatman-Freedman3,4, Hanna Sefty3, Ravit Bassal3, Yaniv Stein3, Tamy Shohat2,3, Ella Mendelson1,2, Musa Hindiyeh1,2, Michal Mandelboim1,2
1Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Ramat-Gan, Israel
2Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
3The Israel Center for Disease Control, Israel Ministry of Health, Tel-Hashomer, Israel
4Departments of Pediatrics and Family and Community Medicine, Valhalla, New York, USA
*These authors contributed equally to this work
Correspondence to:
Michal Mandelboim, email: [email protected]
Keywords: influenza A, H1N1, vaccine, Clade 6B
Received: November 22, 2016 Accepted: March 14, 2017 Published: March 22, 2017
ABSTRACT
The last influenza pandemic, caused by the swine A(H1N1)pdm09 influenza virus, began in North America at 2009. Since then, the World Health Organization (WHO) recommended integration of the swine-based virus A/California/07/2009 strain in yearly vaccinations. Yet, infections with A(H1N1)pdm09 have continued in subsequent years. The reasons for this are currently unknown. During the 2015–2016 influenza season, we noted an increased prevalence of A(H1N1)pdm09 influenza virus infection in Israel. Our phylogenetic analysis indicated that the circulating A(H1N1)pdm09 strains belonged to 6B.1 and 6B.2 clades and differed from the vaccinating strain, with approximately 18 amino acid differences found between the circulating strains and the immunizing A/California/07/2009 strain. Hemmaglutination inhibition (HI) assays demonstrated higher antibodies titer against the A/California/07/2009 vaccinating strain as compared to the circulating Israeli strains. We thus suggest that the current vaccination was not sufficiently effective and propose inclusion of the current circulating A(H1N1)pdm09 influenza viruses in the annual vaccine composition.
![Creative Commons License](/images/80x15.png)
PII: 16459