Loss of nuclear BAP1 expression is associated with poor prognosis in oral mucosal melanoma

Hao Song; Lizhen Wang; Jiong Lyu; Yunteng Wu; Wei Guo; Guoxin Ren

doi:10.18632/oncotarget.16175

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Loss of nuclear BAP1 expression is associated with poor prognosis in oral mucosal melanoma

Hao Song, Lizhen Wang, Jiong Lyu, Yunteng Wu, Wei Guo _ and Guoxin Ren

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:29080-29090. https://doi.org/10.18632/oncotarget.16175

Metrics: PDF 2143 views | HTML 2400 views | ?

Abstract

Hao Song1, Lizhen Wang2, Jiong Lyu3, Yunteng Wu1, Wei Guo1, Guoxin Ren1

1Department of Oral & Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200011, China

2Department of Oral Pathology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200011, China

3Department of Stomatology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang Province, 310003, China

Correspondence to:

Wei Guo, email: [email protected]

Guoxin Ren, email: [email protected]

Keywords: oral mucosa, melanoma, BAP1, prognosis, immunohistochemistry

Received: October 04, 2016 Accepted: January 10, 2017 Published: March 14, 2017

ABSTRACT

Oral mucosal melanoma (OMM) is an aggressive neoplasm with an extremely poor prognosis. BAP1 is a tumor suppressor that has been associated with the outcome of melanomas and other malignancies. In this study, we investigated the genetic alterations in BAP1 and the prognostic potential of BAP1 protein expression in oral mucosal melanoma. DNA sequence analysis of BAP1 from 12 OMM patient samples revealed missense mutations in the tissues from four patients. Based on immunohistochemical staining, loss of nuclear BAP1 expression was associated with poor overall survival (P < 0.001, Log-rank = 21.308) and distant metastasis (P = 0.034, OR = 0.320). Multivariate analysis showed BAP1 to be an independent prognostic factor (P = 0.027, HR = 0.479). It thus appears that loss of nuclear BAP1 expression is an independent prognostic factor of poor overall survival and associated with distant metastasis in OMM.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 16175

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

Loss of nuclear BAP1 expression is associated with poor prognosis in oral mucosal melanoma

Abstract