The prognostic value of histological subtype in patients with metastatic bladder cancer

Cheng Chen; Linkun Hu; Ye Chen; Jianquan Hou

doi:10.18632/oncotarget.16083

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

The prognostic value of histological subtype in patients with metastatic bladder cancer

Cheng Chen, Linkun Hu, Ye Chen and Jianquan Hou _

PDF | HTML | How to cite

Oncotarget. 2017; 8:28408-28417. https://doi.org/10.18632/oncotarget.16083

Metrics: PDF 1680 views | HTML 2618 views | ?

Abstract

Cheng Chen1,*, Linkun Hu1,*, Ye Chen1, Jianquan Hou1

1Department of Urology, the First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China

*These authors contributed equally to this work

Correspondence to:

Jianquan Hou, email: [email protected]

Keywords: urinary bladder neoplasms, histology, distant metastasis, prognosis, survival

Received: December 14, 2016 Accepted: February 28, 2017 Published: March 10, 2017

ABSTRACT

We aim to evaluate the prognostic effect of the histological sub-type in patients with metastatic bladder cancer based on the Surveillance Epidemiology and End Results database. A total of 2634 eligible patients were included. The histological subtypes were: transitional cell carcinoma (TCC; 75.2%); adenocarcinoma (3.3%); squamous cell carcinoma (SQCC; 4.1%); and small cell carcinoma (4.3%). A significant association of adenocarcinoma with better survival outcomes (P < 0.015), and that of SQCC with worse outcomes (P < 0.001) was observed. On multivariate analysis, adenocarcinoma was significantly associated with longer and SQCC with shorter survival time as compared to TCC. Overall, 1331 (50.5%) patients had a single metastatic site and 523 (19.9%) had multiple sites involved. Single-site metastasis had a better survival outcome than multiple metastases (P < 0.001). Histological sub-type and presence of multiple metastatic sites are independent predictors of survival time. Prospective, in-depth research is needed to determine optimal therapeutic strategies for different histological subtypes of bladder cancer with different metastatic patterns.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 16083

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

The prognostic value of histological subtype in patients with metastatic bladder cancer

Abstract