Research Papers:
MMP-11 promoted the oral cancer migration and FAK/Src activation
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Abstract
Chung-Han Hsin1,2, Ying-Erh Chou1,3, Shun-Fa Yang3,4, Shih-Chi Su5, Yi-Ting Chuang4, Shu-Hui Lin4,6 and Chiao-Wen Lin7,8
1School of Medicine, Chung Shan Medical University, Taichung, Taiwan
2Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan
3Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
4Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
5Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan
6Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan
7Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan
8Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan
Correspondence to:
Chiao-Wen Lin, email: [email protected]
Keywords: matrix metalloproteinase, oral squamous cell carcinoma, metastasis, survival, FAK/Src pathway
Received: November 16, 2016 Accepted: February 08, 2017 Published: March 02, 2017
ABSTRACT
Matrix metalloproteinase-11 (MMP-11) has been observed in most invasive human carcinomas. The current study investigated the association between the clinicopathological characteristics and MMP-11 expression in oral squamous cell carcinoma (OSCC) patients. Immunohistochemistry (IHC) staining was performed to assess MMP-11 expression in 279 patients with OSCC. In addition, the metastatic effects of the MMP-11 overexpression on the OSCC cells were also investigated. We found that MMP-11 expression was present in 118/279 (42.3%) cases and expression of MMP-11 was associated with higher incidence of lymph node metastasis and worse grade of tumor differentiation. Importantly, OSCC patients with strong expression of MMP-11 had a significantly lower survival rate (p=0.010). Furthermore, MMP-11 overexpression in OSCC cells increased in vitro cell migration. Mechanistically, MMP-11 increased the cell motility of OSCC cells through focal adhesion kinase/Src kinase (FAK/Src) pathway. In conclusion, our results revealed that the MMP-11 expression in OSCC samples can predict the progression, especially lymph node metastasis, and the survival of OSCC patients in Taiwan.
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PII: 15824