Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications

Ondrej Zenata; Radim Vrzal

doi:10.18632/oncotarget.15697

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications

Ondrej Zenata and Radim Vrzal _

PDF | HTML | How to cite

Oncotarget. 2017; 8:35390-35402. https://doi.org/10.18632/oncotarget.15697

Metrics: PDF 3171 views | HTML 5126 views | ?

Abstract

Ondrej Zenata1 and Radim Vrzal1

1 Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Olomouc, Czech Republic

Correspondence to:

Radim Vrzal, email:

Ondrej Zenata, email:

Keywords: miRNA, phosphorylation, ubiquitination, sumoylation, VDRB1

Received: December 28, 2016 Accepted: February 08, 2017 Published: February 25, 2017

Abstract

Vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. Activated VDR is responsible for maintaining calcium and phosphate homeostasis, and is required for proper cellular growth, cell differentiation and apoptosis. The expression of both phases I and II drug-metabolizing enzymes is also regulated by VDR, therefore it is clinically important.

Post-translational modifications of NRs have been known as an important mechanism modulating the activity of NRs and their ability to drive the expression of target genes. The aim of this mini review is to summarize the current knowledge about post-transcriptional and post-translational modifications of VDR.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 15697

Publication Alerts

Post-Publication Promotion

Publication Discount

Reviews:

Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications

Abstract