Flattened microvessel independently predicts poor prognosis of patients with non-small cell lung cancer

Luo Fang; Ying He; Yinghui Tong; Luying Hu; Wenxiu Xin; Yujia Liu; Like Zhong; Yiwen Zhang; Ping Huang

doi:10.18632/oncotarget.15617

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Flattened microvessel independently predicts poor prognosis of patients with non-small cell lung cancer

Luo Fang, Ying He, Yinghui Tong, Luying Hu, Wenxiu Xin, Yujia Liu, Like Zhong, Yiwen Zhang and Ping Huang _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:30092-30099. https://doi.org/10.18632/oncotarget.15617

Metrics: PDF 1527 views | HTML 1833 views | ?

Abstract

Luo Fang1,2,*, Ying He1,*, Yinghui Tong1, Luying Hu1, Wenxiu Xin1, Yujia Liu1, Like Zhong1, Yiwen Zhang1, Ping Huang1

1Laboratory of Clinical Pharmacy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China

2Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (Lung and Esophagus), Hangzhou, Zhejiang, China

*These authors have contributed equally to this work

Correspondence to:

Ping Huang, email: [email protected]

Keywords: flattened microvessel, aspect ratio, microvessel abnormality, prognosis, non-small cell lung cancer (NSCLC)

Received: October 24, 2016 Accepted: January 27, 2017 Published: February 22, 2017

ABSTRACT

Angiogenesis plays an essential role in improving tumor progression, whereas, its value in prognosis predicting remains controversial, especially in non-small cell lung cancer (NSCLC). Most recently, microvessel pattern has been raised as a novel prognosis factor. In this study, flattened microvessel, evaluated by tumor microvessel aspect ratio (TMAR), was conducted as a prognostic factor in NSCLC patients. A total of 100 patients with NSCLC were retrospectively reviewed. Microvessel in tumor was visualized by immunochemistry staining and then TMAR was determined. The prognostic role of TMAR was evaluated by univariate and multivariate analysis. Most of intratumor microvessels were flattened with a median TMAR of 3.65 (range, 2.43 - 6.28). Patients were stratified into high TMAR group (TMAR ≥ 3.6) and low TMAR group (TMAR < 3.6). Compared with subpopulation with low TMAR, high TMAR had significantly high risk of cancer-related death (univariate analysis: HR = 5.06, 95% CI: 2.44-10.47, p<0.001; multivariate analysis: HR = 4.53, 95% CI: 1.70-12.06, p=0.002).

In conclusion, the results of our study demonstrate that flattened microvessel in tumor tissue is a promising prognosis predictor of NSCLC patients.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 15617

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

Flattened microvessel independently predicts poor prognosis of patients with non-small cell lung cancer

Abstract