The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration

Deting Xue; Erman Chen; Wei Zhang; Xiang Gao; Shengdong Wang; Qiang Zheng; Zhijun Pan; Hang Li; Ling Liu

doi:10.18632/oncotarget.15473

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration

Deting Xue, Erman Chen, Wei Zhang, Xiang Gao, Shengdong Wang, Qiang Zheng, Zhijun Pan, Hang Li _ and Ling Liu

PDF | HTML | How to cite

Oncotarget. 2017; 8:21031-21043. https://doi.org/10.18632/oncotarget.15473

Metrics: PDF 2133 views | HTML 2814 views | ?

Abstract

Deting Xue1, Erman Chen1, Wei Zhang1, Xiang Gao1, Shengdong Wang1, Qiang Zheng1, Zhijun Pan1, Hang Li1, Ling Liu2

1Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, P.R. China

2Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, P.R. China

Correspondence to:

Hang Li, email: [email protected]

Ling Liu, email: [email protected]

Keywords: hesperetin, mesenchymal stem cells, bone regeneration, osteogenesis, gelatin sponge scaffold

Received: January 04, 2017 Accepted: February 08, 2017 Published: February 18, 2017

ABSTRACT

Hesperetin has been suggested to be involved in bone strength. We aimed to investigate the effects of hesperetin on the osteogenic differentiation of human mesenchymal stem cells and its related mechanisms. We showed that hesperetin promoted osteogenic differentiation of human mesenchymal stem cells in vitro. It potentially exerts its effects via the ERK and Smad signaling pathways. Using a rat osteotomy model, we showed that human mesenchymal stem cells combined with a hesperetin/gelatin sponge scaffold resulted in accelerated fracture healing in vivo. Due to the low cost of hesperetin, it could be used as a growth factor for bone tissue engineering or surgical fracture treatment.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 15473

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration

Abstract