Membranous nephropathy associated with hepatitis C virus infection treated with corticosteroids and Ledipasvir-Sofosbuvir: a case report and review of literature

Qinjie Weng; Xiao Li; Hong Ren; Jingyuan Xie; Xiaoxia Pan; Jing Xu; Nan Chen

doi:10.18632/oncotarget.15397

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Membranous nephropathy associated with hepatitis C virus infection treated with corticosteroids and Ledipasvir-Sofosbuvir: a case report and review of literature

Qinjie Weng _, Xiao Li, Hong Ren, Jingyuan Xie, Xiaoxia Pan, Jing Xu and Nan Chen

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Oncotarget. 2017; 8:22299-22303. https://doi.org/10.18632/oncotarget.15397

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Abstract

Qinjie Weng1, Xiao Li1, Hong Ren1, Jingyuan Xie1, Xiaoxia Pan1, Jing Xu1 and Nan Chen1

1 Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Correspondence to:

Nan Chen, email:

Keywords: hepatitis C virus, membranous nephropathy, hepatitis C virus-related glomerulonephritis, Ledipasvir-Sofosbuvir, case report

Received: October 02, 2016 Accepted: January 25, 2017 Published: February 16, 2017

Abstract

Background: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults. As many clinical cases have reported, it may be associated with hepatitis C virus (HCV) infection. Antiviral therapy can be various.

Case summary: We report a case of patient with chronic HCV infection and MN, who presented with was proteinuria. He was treated with ledipasvir and sofosbuvir (Harvoni; Gilead Sciences, Foster City, CA) and was found to be virus-free.

Conclusion: We have reported this case to provide insight into whether Ledipasvir-Sofosbuvir should be administered for HCV-related glomerulonephritis.

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Case Reports:

Membranous nephropathy associated with hepatitis C virus infection treated with corticosteroids and Ledipasvir-Sofosbuvir: a case report and review of literature

Abstract