Oncotarget

Research Papers:

STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer

Lan Zhong, Jing Liu, Yedong Hu, Wei Wang, Fei Xu, Wen Xu, Junyi Han _ and Ewelina Biskup

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Oncotarget. 2017; 8:24354-24361. https://doi.org/10.18632/oncotarget.15396

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Abstract

Lan Zhong1,*, Jing Liu2,*, Yedong Hu1, Wei Wang1, Fei Xu1, Wen Xu1, Junyi Han3, Ewelina Biskup4

1Department of Gastroenterology, East Hospital of Tongji University School of Medicine, Shanghai, China

2State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China

3Department of General Surgery, East Hospital of Tongji University School of Medicine, Shanghai, China

4Department of Internal Medicine, University Hospital of Basel, Switzerland

*These authors contributed equally to this work

Correspondence to:

Junyi Han, email: [email protected]

Keywords: colorectal cancer, metastasis, serine–threonine kinase 31 (STK31), cancer testis antigen

Received: August 25, 2016     Accepted: February 01, 2017     Published: February 16, 2017

ABSTRACT

Purpose: Colorectal cancer (CRC) is the fifth most common cause of cancer deaths in China and fourth worldwide. Metastatic dissemination of primary tumors is considered main cause for CRC related mortality. The serine–threonine kinase 31 (STK31) gene is a novel cancer testis (CT) antigen. It was found significantly highly expressed in gastrointestinal cancers. In our study we aimed to analyze the correlation between STK31 expression patterns and metastasization, tumor stage and grade in CRC patients.

Results: Relative STK31 expression level was significantly higher in patients with lymph node metastasis. STK31 expression levels in primary tumorous tissues of metastatic patients were significantly higher than in ANCTs and in lymph nodes samples, both at the RNA level and the protein level.

Materials and Methods: Surgical specimens of cancerous tissues, paired with adjacent noncancerous tissues, and lymph nodes from 44 CRC cases with different clinicopathological features were collected. Expression of STK31 was detected and measured by immunohistochemistry and quantitative real-time polymerase chain reaction (QRT-PCR).

Conclusions: Our data suggest that STK31 might be a potential biomarker in detecting, monitoring and predicting the metastatic risk of colorectal cancer.


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