Akirin2 promotes slow myosin heavy chain expression by CaN/NFATc1 signaling in porcine skeletal muscle satellite cells

Xiaoling Chen; Yanliu Luo; Zhiqing Huang; Guangmang Liu; Hua Zhao

doi:10.18632/oncotarget.15374

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Research Papers:

Akirin2 promotes slow myosin heavy chain expression by CaN/NFATc1 signaling in porcine skeletal muscle satellite cells

Xiaoling Chen _, Yanliu Luo, Zhiqing Huang, Guangmang Liu and Hua Zhao

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Oncotarget. 2017; 8:25158-25166. https://doi.org/10.18632/oncotarget.15374

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Abstract

Xiaoling Chen1,*, Yanliu Luo1,*, Zhiqing Huang1, Guangmang Liu1, Hua Zhao1

1Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China

*These authors have contributed equally to this work

Correspondence to:

Xiaoling Chen, email: [email protected]

Zhiqing Huang, email: [email protected]

Keywords: Akirin2, slow myosin heavy chain, CaN/NFATc1, porcine skeletal muscle satellite cells

Received: November 01, 2016 Accepted: January 24, 2017 Published: February 16, 2017

ABSTRACT

The objective of this study was to evaluate the effect of Akirin2 on slow myosin heavy chain (slow MyHC, MyHC I) gene expression and its molecular mechanisms. In this study, we showed that the protein expression of Akirin2 in pig slow oxidative Psoas major muscle is higher than that in fast glycolytic tibialis anterior muscle, suggesting that Akirin2 may play a role in myofiber typing. Knockdown of Akirin2 decreased the MyHC I expression and the calcineurin (CaN) activity, and also decreased the expressions of NFATc1 and MCIP1.4. Conversely, overexpression of Akirin2 got the opposite results. Furthermore, inhibition of CaN or knockdown of NFATc1 attenuated Akirin2 overexpression-induced upregulation of MyHC I. Together, these results demonstrate that Akirin2 promotes MyHC I expression via CaN/NFATc1 signaling pathway in porcine skeletal muscle satellite cells.

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Research Papers:

Akirin2 promotes slow myosin heavy chain expression by CaN/NFATc1 signaling in porcine skeletal muscle satellite cells

Abstract