Research Papers:
Association between single nucleotide variants of vascular endothelial growth factor A and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population
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Abstract
Rui Liu1,*, Lifeng Ning1,2,*, Xiaoli Liu3, Huiping Zhang4, Yaqin Yu1, Shangchao Zhang1, Wenwang Rao1, Jieping Shi1, Hui Sun3, Qiong Yu1
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China
2National Research Institute for Family Planning, Beijing 100081, China
3Jilin Provincial Key Laboratory of Surgical Translational Medicine, China-Japan Union Hospital, Jilin University, Changchun 130033, China
4Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
*These authors have contributed equally to this work
Correspondence to:
Qiong Yu, email: [email protected]
Keywords: papillary thyroid carcinoma, nodular goiter, VEGFA, SNPs, Han Chinese
Received: September 01, 2016 Accepted: January 06, 2017 Published: February 02, 2017
ABSTRACT
The aim of the present study was to investigate whether genetic variants in the vascular endothelial growth factor A gene (VEGFA) were risk factors for papillary thyroid carcinoma (PTC) or nodular goiter (NG) in Han Chinese. A total of 2,319 subjects (861 PTC patients, 562 NG patients, and 896 healthy controls) were included. Five tag single nucleotide polymorphisms (tagSNPs: rs3024997, rs3025040, rs833070, rs25648, and rs10434) in VEGFA were genotyped. SNP rs3025040 T allele was associated with a decreased risk of NG (P<0.05). SNP rs3024997 was associated with an increased risk of PTC (P<0.05) and NG (P<0.001) when an over-dominant model (AA+GG vs. AG) was considered. PTC patients carry the less frequent TT genotype (compared to the CC genotype) (P <0.05) of SNP rs3025040. Likewise, NG patients have the less frequent TC genotype compared to the CC (P <0.05). No significant association of SNPs rs833070, rs25648, and rs10434 with PTC or NG was observed. Haplotypes AT (rs3024997 and rs3025040) and GTA (rs10434, rs3025040, and rs3024997) showed a lower risk for NG (P <0.01 and P <0.05, respectively), while haplotypes GTT (rs833070, rs3025040, and rs3024997) and GGGT (rs833070, rs10434, rs3024997, and rs3025040) predicted the risk of progression to NG (both P <0.05). Haplotype AGAC (rs833070, rs10434, rs3024997, and rs3025040) conferred protection for PTC (P <0.05). In summary, this study indicated for the first time that SNPs rs3024997 and rs3025040 in VEGFA were significantly associated with PTC and/or NG. Haplotypes of the VEGFA may influence the risk of PTC and NG.
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