Relationship of thyroid function with intracranial arterial stenosis and carotid atheromatous plaques in ischemic stroke patients with euthyroidism

Junfeng Liu; Xiaoyang Cui; Deren Wang; Simiao Wu; Yao Xiong; Shihong Zhang; Bo Wu; Ming Liu

doi:10.18632/oncotarget.14883

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Clinical Research Papers:

Relationship of thyroid function with intracranial arterial stenosis and carotid atheromatous plaques in ischemic stroke patients with euthyroidism

Junfeng Liu, Xiaoyang Cui, Deren Wang, Simiao Wu, Yao Xiong, Shihong Zhang, Bo Wu and Ming Liu _

PDF | HTML | How to cite

Oncotarget. 2017; 8:46532-46539. https://doi.org/10.18632/oncotarget.14883

Metrics: PDF 1646 views | HTML 2644 views | ?

Abstract

Junfeng Liu1,*, Xiaoyang Cui2,*, Deren Wang1, Simiao Wu1, Yao Xiong1, Shihong Zhang1, Bo Wu1 and Ming Liu1

1 Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China

2 Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, P.R. China

* The first two authors contributed equally to this work

Correspondence to:

Ming Liu, email:

Keywords: free triiodothyronine, free thyroxine, thyroid-stimulating hormone, intracranial artery stenosis, carotid atheromatous plaques

Received: October 02, 2016 Accepted: January 16, 2017 Published: January 28, 2017

Abstract

This study aimed to help clarify the possible relationships of thyroid function with intracranial arterial stenosis or carotid atheromatous plaques in ischemic stroke patients with euthyroidism. We retrospectively reviewed the medical records of a consecutive series of ischemic stroke patients prospectively entered into the Chengdu Stroke Registry between February 2010 and March2012. We performed univariate and multivariate analysis to assess possible relationships of thyroid function with intracranial artery stenosis or carotid atheromatous plaques. Of the 172 patients analyzed (42 women; 61.7 ± 14.0 years old), 62 (32.0%) had carotid atheromatous plaques, and 81 (47.1%) had intracranial artery stenosis. Free thyroxine levels were lower in patients with carotid atheromatous plaques than in patients without plaques (15.80±2.09 vs. 16.92±2.69, P = 0.005).After adjusting for age, gender, hyperlipidemia, and previous smoking, free thyroxine levels were independently associated with carotid atheromatous plaques (OR 0.73, 95% CI 0.54-0.99, P = 0.04). In contrast, thyroid function indicators showed no associations with intracranial arterial stenosis. In conclusion, low free thyroxine levels were independently associated with carotid atheromatous plaques in ischemic stroke patients with euthyroidism, but thyroid function indicators were not associated with intracranial artery stenosis.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 14883

Publication Alerts

Post-Publication Promotion

Publication Discount

Clinical Research Papers:

Relationship of thyroid function with intracranial arterial stenosis and carotid atheromatous plaques in ischemic stroke patients with euthyroidism

Abstract