Oncotarget

Clinical Research Papers:

Feasibility and efficacy of simultaneous off-pump coronary artery bypass grafting and esophagectomy in elderly patients

Ban Liu, Chang Gu, Yuliang Wang, Xiaowei Wang, Wen Ge, Lingtong Shan, Yujian Wei, Xiaohan Xu and Yangyang Zhang _

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Oncotarget. 2017; 8:46498-46505. https://doi.org/10.18632/oncotarget.14824

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Abstract

Ban Liu1,*, Chang Gu2,*, Yuliang Wang3,*, Xiaowei Wang4, Wen Ge5, Lingtong Shan6, Yujian Wei6, Xiaohan Xu4 and Yangyang Zhang7,8

1 Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

2 Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China

3 School of Public Health, Nanjing Medical University, Nanjing, China

4 Department of Cardiovascular Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, China

5 Department of Cardiovascular Surgery, Shuguang Hospital, Affiliated to Shanghai University of TCM, Shanghai, China

6 The First Clinical Medical College of Nanjing Medical University, Nanjing, China

7 Department of Cardiovascular Surgery, East Hospital, Tongji University School of Medicine, Shanghai, China

8 Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, China

* Ban Liu, Chang Gu, and Yuliang Wang contributed equally to this work

Correspondence to:

Yangyang Zhang, email:

Keywords: esophagectomy, off-pump coronary artery bypass grafting, coronary artery disease, simultaneous, outcome

Received: November 22, 2016 Accepted: January 17, 2017 Published: January 26, 2017

Abstract

Introduction: To analyze the outcomes of off-pump coronary artery bypass grafting (OPCABG) and esophagectomy simultaneously for patients with coronary artery disease (CAD) and coexisting esophageal cancer.

Methods: Twenty-two patients with CAD and coexisting esophageal cancer underwent combined surgical interventions were subjected to the study. OPCABG was performed first, followed by esophagectomy. All the corresponding data including clinicopathological characteristics and postoperative outcomes were all investigated.

Results: All the combined procedures were performed successfully. The average number of grafts was 2.36. Tumors were located at the middle third of the esophagus in 5 patients, at the lower third of the esophagus in 8 patients, at the esophageal gastric junction (EGJ) in 9 patients, respectively. The operations were carried out through a left lateral thoracotomy approach in 21 patients while a median sternotomy and left lateral thoracotomy approach was used in 1 patient for his condition rapidly worsened. Postoperatively, pneumonia occurred in 4 patients (18.2%). During the follow-up, three patients died of cancer metastasis /recurrence (6, 18, 37 months) and one died of pneumonia (1 month). The cumulative 5 years survival rate is 52.9%.

Conclusions: The combined procedure of OPCABG and esophagectomy is a safe and effective treatment option for patients with severe CAD and esophageal cancer.


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