Targeting microRNAs: a new action mechanism of natural compounds

Qian Lin; Leina Ma; Zhantao Liu; Zhihong Yang; Jin Wang; Jia Liu; Guohui Jiang

doi:10.18632/oncotarget.14392

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Targeting microRNAs: a new action mechanism of natural compounds

Qian Lin, Leina Ma, Zhantao Liu, Zhihong Yang, Jin Wang, Jia Liu _ and Guohui Jiang

PDF | HTML | How to cite

Oncotarget. 2017; 8:15961-15970. https://doi.org/10.18632/oncotarget.14392

Metrics: PDF 3016 views | HTML 3248 views | ?

Abstract

Qian Lin1, Leina Ma2, Zhantao Liu1, Zhihong Yang1, Jin Wang1, Jia Liu1 and Guohui Jiang1

1 College of Medicine, Qingdao University, Qingdao, China

2 The Department of Oncology, The First Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China

Correspondence to:

Jia Liu, email:

Guohui Jiang, email:

Keywords: natural compounds; miRNAs; cancer

Received: September 20, 2016 Accepted: December 01, 2016 Published: December 30, 2016

Abstract

Unlike genetics, epigenetics involves the modification of genome without changes in DNA sequences, including DNA methylation, histone modification, chromatin remodeling and noncoding RNA regulation. MicroRNA (miRNA), a member of noncoding RNAs superfamily, participates in RNA interference through a unique mechanism. Currently, microRNAs have been found to be regulated by some natural compounds. Through altering the expression of miRNAs and influencing the downstream signaling pathways or target genes, several natural compounds exhibit its bioactivity in the prevention, diagnosis, therapy, prognosis and drug resistance of human diseases, such as cancer. In this review, several natural compounds and their studies about miRNA-related action mechanism were summarized. These studies provide a new insight into action mechanism by which natural compound exerts its bioactivity and a novel treatment strategy, demonstrating natural compound a promising remedy for clinical treatments.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 14392

Publication Alerts

Post-Publication Promotion

Publication Discount

Reviews:

Targeting microRNAs: a new action mechanism of natural compounds

Abstract