Cytotoxic lanostane-type triterpenoids from the fruiting bodies of  Ganoderma lucidum  and their structure–activity relationships

Shaodan Chen; Xiangmin Li; Tianqiao Yong; Zhanggen Wang; Jiyan Su; Chunwei Jiao; Yizhen Xie; Burton B. Yang

doi:10.18632/oncotarget.14336

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships

Shaodan Chen, Xiangmin Li, Tianqiao Yong, Zhanggen Wang, Jiyan Su, Chunwei Jiao, Yizhen Xie and Burton B. Yang _

PDF | HTML | How to cite

Oncotarget. 2017; 8:10071-10084. https://doi.org/10.18632/oncotarget.14336

Metrics: PDF 2779 views | HTML 3448 views | ?

Abstract

Shaodan Chen1,2,*, Xiangmin Li1,2,*, Tianqiao Yong1,2,*, Zhanggen Wang3, Jiyan Su1,2, Chunwei Jiao2, Yizhen Xie1,2, Burton B. Yang4,5

1State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China

2Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China

3College of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China

4Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada

5Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

*These authors have contributed equally to this work

Correspondence to:

Yizhen Xie, email: [email protected]

Burton B. Yang, email: [email protected]

Keywords: Ganoderma lucidum, lanostane-type triterpenoids, cytotoxicity, 3D-QSAR

Received: July 25, 2016 Accepted: December 01, 2016 Published: December 28, 2016

ABSTRACT

We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line HepG2. Corresponding three-dimensional quantitative structure–activity relationship (3D-QSAR) models were built and analyzed using Discovery Studio. These results provide further evidence for anti-cancer constituents within Ganoderma lucidum, and may provide a theoretical foundation for designing novel therapeutic compounds.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 14336

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships

Abstract