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CD44v6 overexpression related to metastasis and poor prognosis of colorectal cancer: A meta-analysis

Ji-Lin Wang _, Wen-Yu Su, Yan-Wei Lin, Hua Xiong, Ying-Xuan Chen, Jie Xu and Jing-Yuan Fang

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Oncotarget. 2017; 8:12866-12876. https://doi.org/10.18632/oncotarget.14163

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Abstract

Ji-Lin Wang1,*, Wen-Yu Su1,*, Yan-Wei Lin2, Hua Xiong1, Ying-Xuan Chen1, Jie Xu1, Jing-Yuan Fang1

1Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China

2Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China

*These authors have contributed equally to this work

Correspondence to:

Ji-Lin Wang, email: [email protected]

Jie Xu, email: [email protected]

Jing-Yuan Fang, email: [email protected]

Keywords: CD44v6, prognosis, colorectal cancer, meta-analysis

Received: October 04, 2016    Accepted: November 24, 2016    Published: December 24, 2016

ABSTRACT

CD44v6 has recently been reported as a biomarker for colorectal cancer. However, the clinical and prognostic significance of CD44v6 in colorectal cancer remains controversial. Therefore, we performed a meta-analysis to clarify this issue. A comprehensive literature search was performed using Medline, Embase and Web of Science, and the statistical analysis was conducted using Stata software. A total of twenty-one studies including 3918 colorectal cancer cases were included. The pooled analysis showed that CD44v6 overexpression in colorectal cancer was an independent prognostic marker correlating with lower 5-year overall survival rate (OR=0.78, 95%CI =0.67-0.91, p=0.001). CD44v6 overexpression was also associated with more lymph node invasion (OR=1.48, 95%CI= 1.02-2.15, p=0.04), and advanced Dukes stage (OR=2.47, 95%CI= 1.29-4.73, p=0.01). In addition, while excluding Zolbec’s study, CD44v6 overexpression was associated with distance metastasis (OR=1.65, 95%CI =1.13-2.40, p=0.01). Taken together, this meta-analysis suggested that CD44v6 is an efficient prognostic factor in colorectal cancer.


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