Research Papers:
Squamous cell carcinoma antigen (SCCA) is up-regulated during Barrett’s carcinogenesis and predicts esophageal adenocarcinoma resistance to neoadjuvant chemotherapy
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Abstract
Matteo Fassan1, Stefano Realdon2, Luca Vianello1, Santina Quarta3, Alberto Ruol4, Carlo Castoro5, Marco Scarpa5, Giovanni Zaninotto6, Vincenza Guzzardo1, Vanna Chiarion Sileni7, Patrizia Pontisso3, Massimo Rugge1,8
1Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy
2Gastroenterology Unit, Istituto Oncologico Veneto, IOV-IRCCS, Padua, Italy
3Department of Medicine (DIMED), 5th Medical Clinic, University of Padua, Padua, Italy
4Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), 3rd Surgical Clinic, University of Padua, Padua, Italy
5Esophageal and Digestive Tract Surgical Unit, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy
6Imperial College London, Department of Surgery and Cancer, Division of Surgery, London, UK
7Melanoma & Esophageal Oncology Unit, Istituto Oncologico Veneto, IOV-IRCCS, Padua, Italy
8Veneto Tumour Registry, Veneto Region, Padua, Italy
Correspondence to:
Patrizia Pontisso, email: [email protected]
Keywords: SCCA, esophageal adenocarcinoma, Barrett’s carcinogenesis, preneoplastic lesions
Received: July 29, 2016 Accepted: November 22, 2016 Published: December 22, 2016
ABSTRACT
Squamous Cell Carcinoma Antigen (SCCA) is consistently overexpressed in many different solid tumors, and has been associated with both tumor aggressiveness and chemoresistance. No data, however, is currently available on SCCA expression during esophageal Barrett’s carcinogenesis, nor on SCCA expression’s role on esophageal adenocarcinoma chemoresistance. The SCCA immunohistochemical expression was assessed in a series of 100 biopsy samples covering the whole histological spectrum of Barrett’s oncogenesis. Squamous native mucosa was characterized by a moderate to strong cytoplasmic and nuclear SCCA expression in suprabasal, medium, and superficial layers. On the other hand, almost half of the considered lesions did not express SCCA; the other half featured weak to moderate SCCA expression. The relationship between SCCA protein expression and tumor response to neoadjuvant chemotherapy was assessed in 90 esophageal adenocarcinoma specimens (40 biopsy and 50 surgery specimens), stratified according to Mandard tumor regression grade. As observed in other settings, the presence of SCCA expression clustered in the group of tumors characterized by a lower responsiveness to neoadjuvant treatments. The present results suggest an involvement of SCCA in a subset of Barrett-related tumors, and prompt to consider the SCCA-protein expression as response-predictive marker of neoadjuvant therapy in esophageal adenocarcinomas.
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PII: 14108